津血源颗粒对干燥综合征（SS）鼠的实验研究

目的:探讨津血源颗粒对干燥综合征(SS)模型鼠的治疗作用。方法:采用弗氏完全佐剂和百日咳、白喉、破伤风联合疫苗 同种鼠颌下腺抗原诱导,同时每天以0.6mg/kg利血平与50mg/kg甲状腺素灌胃,连续4周,建立类似临床SS动物模型。以津血源颗粒对SS模型鼠进行干预,观察津血源颗粒对SS模型鼠唾液分泌功能、体重、摄食量、饮水量、胸腺和颌下腺指数的影响。结果:津血源颗粒可以增加SS模型鼠的进食量、体重和唾液分泌量,缓解其口干症状,减少其饮水量,延缓SS模型鼠胸腺和颌下腺萎缩。结论:津血源颗粒可明显改善SS模型鼠的症状,对SS具有一定的治疗作用。

Empirical Study of Sicca Syndrome(SS) on Model Rats with Jinxieyuan Granula

Objeetive:To study the therapeutic action of healing sicca syndrome(SS) on model rats with Jinxieyuan Granula.Methods:use Freund's complete adjuvant,pertussis,diphtheria,tetanus combined vaccine and glandula angularis of the same race rats antigen derivation.Supply intragastric administration with 0.6mg/kg apoplon and 50mg/kg tetraiodothyronine to establish animal model of clinical SS.Interfere in SS model rats with Jinxieyuan Granula and observe its effect on SS model rats with salivary secretion function,body weight,food-intake,watere-intake and the exponent of thoracic gland and glandula angularis.Results:Jinxieyuan Granula can increase food-intake,body weight and salivary secretion of model rats.It also can elieve dry mouth symptom,decrease watere-intake and delay the analosis of thoracic gland and glandula angularis on model rats.Conclusion: Jinxieyuan Granula can obviously improve the symptom of SS model rats.It has positive therapeutic action with SS.