IgA肾病湿热证与临床病理的相关性研究

目的:研究IgA肾病湿热证与临床病理的相关因素分析。方法:分析53例IgA肾病湿热证与53例非湿热证患者的临床及肾脏病理资料。结果:IgA肾病湿热证的中医宏观辨证中最常见的症候是咽喉肿痛,其次是小便黄赤、灼热或涩痛不利;临床伴肉眼血尿,有感染诱因者比非湿热证组多见,表现为肾病综合征比非湿热证组少;血C反应蛋白水平显著高于非湿热证组;肾小球细胞增殖积分显著高于非湿热证组。结论:IgA肾病湿热证与临床指标及肾组织病理有一定相关性,中医宏观辨证与西医微观辨证的结合将更有利于揭示IgA肾病湿热证的本质,为证的客观化研究提供一定依据。

Study on the Relationship Between Damp-heat Syndrome and Clinical Pathology in IgA Nephropathy Patients

Objective:To observe the relationship between damp-heat syndrome and clinical pathology in patients with IgA nephropathy(IgAN).Methods:We collect the clinicopathological materials of 53 patients with damp-heat syndrome,and 53 patients with non damp-heat syndrome.Result:In patients with damp-heat syndrome,swelling and aching of throat was the symptom most commonly seen;often accompanied with gross hematuria and had more inducement of infection,few with nephrotic syndrome.Compared with patients of non damp-heat syndrome,plasma levels of creactive protein(CRP),was obviously higher,and scores of glomerular cell multiplication significantly higher.Conclusion:Damp-heat syndrome of IgAN are correlated with certain clinical parameters and renal pathological changes.The combination of TCM holistic syndrome differentiation and Western medicinal micro-differentiation is more favorable for making c1ear the nature of damp-heat syndrome of IgAN.It may provide some guidances for the objectivise of "syndrome".