| 姜黄素抗博莱霉素诱导大鼠肺纤维化的实验研究 |
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| 引用本文： | 李银生,牛建昭,王继峰,周刚,李亚东,陈伟涛,李泽华.姜黄素抗博莱霉素诱导大鼠肺纤维化的实验研究[J].中华中医药学刊,2007,25(4):698-700. |
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| 作者姓名： | 李银生 牛建昭 王继峰 周刚 李亚东 陈伟涛 李泽华 |
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| 作者单位： | [1]北京中医药大学细胞生物化学实验室,北京100029 [2]新乡医学院组织学与胚胎学教研室,河南新乡453003 |
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| 基金项目： | 教育部“长江学者和创新团队发展计划”资助项目（1RT0413）;国家自然科学基金资助（30672757）;科技部国际合作计划资助（2006DFA31230） |
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| 摘 要： | 目的：探讨姜黄素对博莱霉素（BLM）致肺纤维化的治疗作用。方法：复制大鼠博莱霉素致肺纤维化模型，采用光镜观察组织学改变，测定肺组织羟脯氨酸（Hyp）、超氧化物歧化酶（SOD）、丙二醛（MDA）以反映肺细胞损伤及肺纤维化的程度。结果：姜黄素能降低实验性肺纤维化大鼠过高的肺组织中Hyp、MDA的含量，提高大鼠体内的SOD的含量。病理组织学检查亦表明，姜黄素明显改善实验性肺纤维化。结论：姜黄素对实验性肺纤维化具有一定的治疗作用。
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| 关 键 词： | 肺纤维化 姜黄素 脂质过氧化 |
| 文章编号： | 1673-7717（2007）04-0698-03 |
| 收稿时间： | 2006-11-14 |
| 修稿时间： | 2006-11-14 |
Effect of Curcumin against Bleomycin -Induced Pulmonary Fibrosisin Rats |
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| LI Yin-sheng, NIU Jian-zhao ,WANG Ji-feng , ZHOU Gang , LI Ya-dong , CHEN Wei-tao, LI Ze-hua.Effect of Curcumin against Bleomycin -Induced Pulmonary Fibrosisin Rats[J].Chinese Archives of Traditional Chinese Medicine,2007,25(4):698-700. |
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| Authors: | LI Yin-sheng NIU Jian-zhao WANG Ji-feng ZHOU Gang LI Ya-dong CHEN Wei-tao LI Ze-hua |
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| Institution: | 1. laboratory of Cell and Biochemistry, Beijing University of TCM, Beijing 100029, China; 2. Xinxiang Medical College, Xinxdang 453003, Henan, China |
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| Abstract: | Objective:To investigate the curative effect of curcumin on pulmonary fibrosis in rats induced by Bleomycin.Methods: Model of pulmonary fibrosis in rats was induced by Bleomycin by subcutaneous injection of Bleomycin and they were treated with curcumin.The histological changes were observed with microscope.The levels of Hyp,MDA in pulmonary tissue were determined to reveal the event pulmonary damage.Results: Curcumin significantly reduced the elevate levels of Hyp,MDA in pulmonary tissue.Pathological examination suggested curcumin has the rapeutic effecton experimental pulmonary fibrosis wih significant.Conclusion: Curcumin may have the rapeutic effecton Bleomycin-induced pulmonary fibrosis in rats. |
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| Keywords: | pulmonary fibrosis curcumin lipidperoxidation |
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