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温肾壮骨汤联合钙制剂及维生素D治疗老年性骨质疏松症临床研究
引用本文:范琳燕.温肾壮骨汤联合钙制剂及维生素D治疗老年性骨质疏松症临床研究[J].国际中医中药杂志,2016(8):705-708.
作者姓名:范琳燕
作者单位:510375广州中医药大学附属骨伤科医院治未病中心
摘    要:目的:评价温肾壮骨汤联合钙制剂及维生素 D 治疗老年性骨质疏松症(osteorosis pathological, OP)的疗效。方法将符合入选标准的82例老年OP患者采用随机数字表法分为2组各41例。对照组给予常规治疗(钙制剂、维生素D),观察组在对照组基础上加服温肾壮骨汤。2组均连续治疗10周,随访3个月。观察治疗前后老年OP患者骨密度(bone mineral density, BMD)、骨钙素(osteocalcin, BGP)、骨碱性磷酸酶(bone-specific alkaline phosphatase, BALP)的变化,评价疗效及不良反应发生情况。结果观察组总有效率为90.24%(37/41)、对照组为70.73%(29/41),2组比较差异有统计学意义(χ2=4.970,P=0.026)。治疗后,观察组 BMD(0.84±0.05)g/cm2比(0.78±0.06)g/cm2, t=4.919]、BGP(28.64±12.14)ng/ml比(21.32±11.25)ng/ml,t=2.832]、BALP(18.11±6.15)U/L比(14.54±6.21)U/L,t=2.615]高于对照组(P<0.01或 P<0.05)。治疗期间,观察组不良反应发生率为7.32%(3/41)、对照组为24.39%(10/41),2组比较差异有统计学意义(χ2=4.479,P=0.034)。随访3个月,对照组OP性骨折率为26.83%(11/41)、观察组为9.76%(4/41),2组比较差异有统计学意义(χ2=3.400,P=0.045)。结论温肾壮骨汤联合钙制剂及维生素D可改善老年OP患者症状,预防老年性OP骨折。

关 键 词:骨质疏松  老年人  类钙剂  维生素D  温肾壮骨汤  骨密度  骨钙素  碱性磷酸酶

Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the ;treatment of senile osteoporosis
Abstract:Objective To evaluate the clinical effects of Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the treatment of senile osteoporosis. Methods A total of 82 patients with osteoporosis were randomly divided into the control group and the observation group, 41 in each group. The control group was given conventional treatment (calcium preparations, vitamin D). Based on the treatment of control group, the observation group was combined with traditional Chinese medicine (TCM) formula Wenshen-Zhuanggu decoction. Both groups were treated for 10 weeks, and followed up for 3 months. The improvement of osteoporosis, bone function related indexes bone mineral density (BMD), serum bone gla protein (BGP), serum bone alkaline phosphatase (BALP) and incidence of osteoportic fractures and adverse reactions in the two groups were observed. Results The effective rate of symptom remission in the observation group was 90.24% (37/41) while in the control group was 70.73% (29/41) (χ2=4.970, P<0.05), and the bone function related indexes of both groups (BMD, BGP, BALP) were significantly improved after treatment. Compared with the control group, the BMD (0.84 ± 0.05 g/cm2 vs. 0.78 ± 0.06 g/cm2, t=4.919), BGP (28.64 ± 12.14 ng/ml vs. 21.32 ± 11.25 ng/ml, t=2.832) and BALP (18.11 ± 6.15 U/L vs. 14.54 ± 6.21 U/L, t=2.615) in the observation group were significantly higher than those in the control group (P<0.05). The incidence rates of adverse reactions (7.32%vs. 24.39%) and osteoportic fractures (9.76%vs. 26.83%) in the observation group were significantly lower than those in the control group (P<0.05). Conclusions Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the treatment of senile osteoporosis can effectively alleviate symptoms and preventing senile OP fractures..
Keywords:Osteoporosis  Aged  Calcimimetic agents  Vitamin D  Wenshen-Zhuanggu decoction  Bone density  Osteocalcin  Alkaline phosphatase
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