中西医结合治疗糖尿病周围神经病变的疗效观察

目的 研究丹红注射液联合甲钴胺注射液对糖尿病周围神经病变(DPN)的临床疗效.方法 将符合1999年ADA标准诊断为2型糖尿病的72例患者随机分为治疗组和对照组,治疗组静脉滴注丹红注射液,20ml/d,同时肌肉注射甲钴胺注射液500 μg/d;对照组仅肌肉注射甲钴胺注射液.2周后观察其临床疗效及测定运动神经传导速度(MNCV)、感觉神经传导速度(SNCV).结果 治疗组患者临床总有效率92.1%;对照组总有效率67.6%,两组比较有显著性差异(P＜0.01).治疗组治疗前后SNCV、MNCV均有显著性差异(P＜0.01);治疗后两组比较有显著性差异(P＜0.05),两组均无明显的不良反应.结论 丹红注射液与甲钴胺注射液联合应用优于单独应用甲钴胺注射液对DPN的治疗效果.

Clinical Observation on Therapeutic Effects of Treatment of Diabetic Peripheral Neuropathy with Integrative Traditional Chinese and Western Medicine

Objective To evaluate the clinical efficacy of Dan-Hong Injection and Methycobal combined therapy in treating diabetic peripheral neuropathy(DPN).Methods 72 cases of peripheral neuropathy and type 2 diabetes(conformed to ADA standard published in 1999)were randomly separated into an experimem group and a control group.Members in the experiment group were treated with Dan-Hong injection 20ml/day i.v.and Methycobal 500ug/day i.m.Members in the control group were treated with Methycobal only.At the end of 2 weeks'therapeutic courses,motor nerve conducdon velocity (MNCV)and sural nerve conduction velocity(SNCV)were evaluated.Results The overall effective rate was 92.1% in the experiment group and 67.6% in the control group,showing significant difference between the two groups(P＜0.01).The post-therapeutic values of both SNCV and MNCV were significantly different from those of previous treatment.(P＜0.01)The post-therapeutic values of SNCV and MNCV of the experiment group were also significantly different from those of the control group(P＜0.05).No evidently relative adverse effects were observed in both groups.Conclusions Combined therapy of Dan-Hong injection and Methycobal was more effective in controlling the clinical activity of diabetic peripheral neuropathy.