溃愈散对溃疡性结肠炎患者血清白细胞介素6、白细胞介素8的影响

目的 探讨溃愈散治疗溃疡性结肠炎(ulcerative colitis,UC)的临床疗效及其作用机制.方法 将120例溃疡性结肠炎患者按照完全随机方法分为两组各60例,治疗组采用溃愈散保留灌肠治疗,1次/d;对照组口服柳氮磺胺吡啶片,1g/次,3次/d,两组患者均治疗15d为1个疗程,间隔后7d进行下个疗程,3个疗程后比较两组患者的临床综合疗效、主要症状、结肠镜镜检积分改善情况,以及治疗前后患者血清白细胞介素6 (IL-6)、白细胞介素8(IL-8)的水平变化,治疗后对两组完全缓解及有效病例随防6个月,观察其复发率.结果 治疗组总有效率为93.33％,优于对照组78.33％(x2=9.027,P＜0.05);治疗后治疗组较对照组在腹泻、脓血便的改善上更为明显(x2值分别为5.630、5.972,P＜0.05),能明显降低UC患者血清IL-6、IL-8的水平(x2=8.314,P＜0.01);结肠镜镜检积分显示两组治疗后充血、糜烂、溃疡均有明显改善,治疗组优于对照组(x2=8.322,P＜ 0.05);随访6个月,治疗组复发率低于对照组,差异有统计学意义(x2=5.857,P＜0.05).结论 溃愈散通过下调IL-6、IL-8水平治疗溃疡性结肠炎,缓解率高、安全性好.

Study on influences of Kuiyu dection on contents of IL-6 and IL-8 in patients with ulcerative colitis

Objective To observe the effect of Kuiyu dection on ulcerative colitis and to explore its mechanism. Methods 120 patients with ulcerative colitis were randomly divided into a treatment group and a control group, 60 cases in each group. The treatment group was treated with Kuiyu dection retention enema, 1 time a day, 15 days for a course of treatment; and the control group was treated with SASP orally, 2 g every time,3 times a day, and 15 days for a course of treatment. All patients with a course of treatment for the next 7 days after the rest period of treatment, evaluated after 3 courses. Comprehensive clinical efficacy, the main symptoms, score of integral electronic colonoscopy examination, and the changes of IL-6, IL 8 levels were observed in both groups after treatment with complete remission and six months followed-up, besides, the recurrence rate was also observed. Results The total effective rate was 93.33% in the treatment group, better than the control group 78.33% （x^2=9.027, P〈0.05） ; the treatment group also showed better results in diarrhea, pus and blood improvement than the control group （x^2= 5.630, x^2= 5.972, P〈0.05）, the treatment group could significantly reduce UC Serum IL-6, IL-8 level （x^2=8.314, P〈0.01）; electronic colonoscopy examination points, hyperemia, erosions, ulcers in both groups were significantly improved, but the treatment group was significantly better than the control group （x^2=8.322, P〈0.05） ; 6 months followed-up and the recurrence rate in treatment group were better than control group, and the difference was statistically significant （x^2=5.857, P〈 0.05）. Conclusion Through decreasing the IL-6, IL 8 levels, Kuiyu dection can treat ulcerative colitis, with significant effect, non-toxic side effects, inexpensive, and easy for use.