| 藤茶总黄酮清除氧自由基与抗脂质过氧化作用 |
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| 引用本文： | 何桂霞,杜方麓,杨伟丽,裴刚,朱咏华.藤茶总黄酮清除氧自由基与抗脂质过氧化作用[J].中药材,2003,26(5):338-340. |
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| 作者姓名： | 何桂霞 杜方麓 杨伟丽 裴刚 朱咏华 |
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| 作者单位： | 1. 湖南中医学院,长沙,410007
2. 湖南农业大学食品科技学院,长沙,410128 |
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| 摘 要： | 目的：研究藤茶总黄酮(Tengcha flavonoids，TCF)清除氧自由基与抗脂质过氧化作用。方法：以黄嘌呤—黄嘌呤氧化酶系统产生的超氧阴离子自由基，研究TCF对氧自由基的清除作用；以Vc—Fe^2 系统诱导大鼠肝匀浆及肝线粒体产生的脂质过氧产物，研究TCF抗脂质过氧化作用。结果：TCF能清除氧自由基，其IC50为14．7mg／L；能抑制大鼠肝匀浆自氧化及和Vc—Fe^2 系统诱导引起的脂质过氧化，对肝线粒体也有保护作用，并呈浓度依赖关系。结论：TCF对氧自由基有清除作用，并能预防性对抗超氧阴离子自由基引起的氧化性损伤。
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| 关 键 词： | 藤茶总黄酮 氧自由基 抗脂质过氧化作用 超氧阴离子自由基 |
| 修稿时间： | 2002年10月8日 |
Effects of Tengcha Flavonoids on Scavenging Oxygen Free Radicals and Inhibiting Lipid-Peroxidation |
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| He Guixia,Du Fanglu,Yang Weili,Pei Gang,Zhu Yonghua.Effects of Tengcha Flavonoids on Scavenging Oxygen Free Radicals and Inhibiting Lipid-Peroxidation[J].Jorunal of Chinese Medicinal Materials,2003,26(5):338-340. |
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| Authors: | He Guixia Du Fanglu Yang Weili Pei Gang Zhu Yonghua |
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| Institution: | Hunan College of Traditional Chinese Medicine, Changsha 410007. |
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| Abstract: | Objective:To study the effects of Tengcha flavonoids (TCF) on scavenging oxygen free radicals and inhibiting lipid-peroxidation. Methods: The effects of TCF on scavenging superoxide anion radical induced by xanthine-xanthine oxidase, inhibiting lip-id-peroxidation of heart, liver, brain tissue homogenate and mitochondria induced by Fe2+-VitC, Fe 2+-H2O2, Fe-Cys were discussed by TBA spectrometric method. Results:TCF could significantly inhibit the superoxide anion radical, IC50 is 14. 7 mg/L, and the lipid peroxidation of liver homogenate and mitochondria induced by auto-oxidation and induced-oxidation. The inhibiton exhibited concentration-dependent manner. Conclusion:It indicated that TCF could scavenge oxygen free radicals and was capable of prophylaeticly antagonizing against the oxidative injury by superoxide anion. |
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| Keywords: | Ampelopsis grossedentala Tengcha flavonoids Lipid peroxidation |
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