| 桃花止泻冲剂的药效学研究 |
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| 引用本文： | 山丽梅,赵艳玲,肖小河,蔡光明,贺承山.桃花止泻冲剂的药效学研究[J].中药材,2003,26(6):420-422. |
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| 作者姓名： | 山丽梅 赵艳玲 肖小河 蔡光明 贺承山 |
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| 作者单位： | 解放军302医院,北京,100039 |
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| 基金项目： | 军队十五攻关项目基金 ( 0 1Q13 6)资助 |
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| 摘 要： | 采用炭末推进法和药物性腹泻模型,观察了桃花止泻冲剂对小鼠小肠推进运动、药物性腹泻的影响,并初步观察桃花止泻冲剂的抗炎作用。结果表明,桃花止泻冲剂能明显抑制新斯的明引起的小鼠小肠推进亢进作用,减少番泻叶引起的小鼠腹泻发生率和次数,并具有剂量依赖性。桃花止泻冲剂11．70和17．55g／kg剂量组能明显抑制乙酸引起小鼠腹腔毛细血管通透性的增高。
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| 关 键 词： | 桃花止泻冲剂 药效学 腹泻 抗炎作用 小鼠 毛细血管通透性 |
| 修稿时间： | 2002年12月23 |
Pharmacodynamics Study on "Tao Hua Zhi Xie Granule" |
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| Shan Limei,Zhao Yanlin,Xiao Xiaohe,Cai Guangming,He Chengshan.Pharmacodynamics Study on "Tao Hua Zhi Xie Granule"[J].Jorunal of Chinese Medicinal Materials,2003,26(6):420-422. |
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| Authors: | Shan Limei Zhao Yanlin Xiao Xiaohe Cai Guangming He Chengshan |
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| Institution: | 302 Hospital of PLA, Beijing 100039. |
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| Abstract: | The anthraco propulsion and the drug induced mice diarrhea models were used to observe the intestine propulsion and the anti diarrhea effect of "Tao Hua Zhi Xie Granule"(THZXG),and the anti inflammation effect of THZXG was studied.The results showed that THZXG could obviously reduce the incidence and frequency of the mice diarrhea induced by Folium Sennae and castor oil,and propelling movement of mice small intestine after hypodermic injection of neostigmine.The actions were acted in a dose dependent manner. 11.70 and 17.55 mg/kg THZXG(ig) could also inhibit the increased permeability of intraperitoneal capillary induced by acetic acid in mice. |
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| Keywords: | Tao Hua Zhi Xie Granule" Diarrhea |
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