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加减鳖甲煎治疗肝硬化失代偿期的临床研究
引用本文:王拥泽,杨宏志,林炳亮,谢和平,李永伟,戴敏.加减鳖甲煎治疗肝硬化失代偿期的临床研究[J].中药材,2007,30(6):755-757.
作者姓名:王拥泽  杨宏志  林炳亮  谢和平  李永伟  戴敏
作者单位:中山大学附属第三医院,广东广州,510630
基金项目:广东省中医药管理局研究课题
摘    要:目的:观察中药加减鳖甲煎与西药结合治疗失代偿期肝硬化的临床疗效。方法:98例失代偿期肝硬化住院患者,随机分为两组,治疗组49例,对照组49例,两组均以相同的西药治疗,护肝支持及对症处理,治疗组加服加减鳖甲煎。结果:两组治疗后天冬氨酸氨基转移酶(AST),丙氨酸氨基转移酶(ALT),血清总胆红素(TB),肝纤四项均有下降(P<0.05),凝血酶原活动度(PTA)有所回升。组间比较示治疗组TB、直接胆红素(DB)、肝纤维化指标降低及PTA回升更优(P<0.05)。结论:加减鳖甲煎治疗失代偿期肝硬化,具有较好的退黄,减轻肝纤维化,改善凝血功能的疗效。

关 键 词:加减鳖甲煎  肝硬化  肝纤四项  胆红素  凝血功能
文章编号:1001-4454(2007)06-0755-03
修稿时间:2007-03-19

The Clinical Study on Decompensatory Cirrhotic Patients Treated by Bie Jia Jian
WANG Yong-ze,YANG Hong-zhi,LIN Bing-liang,XIE He-ping,LI Yong-wei,DAI Min.The Clinical Study on Decompensatory Cirrhotic Patients Treated by Bie Jia Jian[J].Jorunal of Chinese Medicinal Materials,2007,30(6):755-757.
Authors:WANG Yong-ze  YANG Hong-zhi  LIN Bing-liang  XIE He-ping  LI Yong-wei  DAI Min
Institution:The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
Abstract:OBJECTIVE: To observe the clinical curative effect on decompensatory cirrhotic patients treated by Bie Jia Jian. METHODS: 98 decompensatory cirrhotic patients were randomly divided into two groups: 49 patients in treatment group and 49 in control group. Both groups were treated with the same western medicine of protecting and supporting liver. Except that, treatment group were treated by Bie Jia Jian. RESULTS: The Contents of AST, ALT, total bilirubin (TB), direct bilirubin (DB), hyaluronic acid (HA), Laminin (LN) , procollagen III (pc III), and type IV collagen (IV.C) in both groups decreased after treatment, and prothrombin time activity (PTA) increased. Among them, the decrease of TB, DB, HA, LN, PC-III and IV-C, and the increase of PTA in treatment group were more obvious than those in control group (P < 0. 05). CONCLUSION: Bie Jia Jian is effective in treating decompesatory cirrhotic patients.
Keywords:Bie Jia Jian  Cirrhotic  Liver fibrosis  Bilirubin  Hemoglutination function
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