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| 沙棘油重建造血功能的实验研究 | |
| 引用本文： | 陈运贤,钟雪云,刘天浩,葛志红.沙棘油重建造血功能的实验研究[J].中药材,2003,26(8):572-575. |
| 作者姓名： | 陈运贤 钟雪云 刘天浩 葛志红 |
| 作者单位： | 1. 中山大学附属第一医院,广州510080 2. 暨南大学医学院,广州510630 3. 中山大学附属孙逸仙纪念医院,广州510120 4. 广东省中医院,广州510120 |
| 基金项目： | 广东省科技厅，卫生厅社会发展协作攻关项目( 2 0 0 2B3 0 2 0 2 )，广州市科技局基金项目 ( 2 0 0 1 Z 0 43 0 1 8) |
| 摘 要： | 目的：探索沙棘油支持大剂量化疗，重建化疗后造血功能的可能性。方法：观察沙棘油灌胃前后小鼠血细胞数值的变化以及沙棘油重建化疗后造血功能障碍动物模型造血功能的作用。结果：沙棘油灌胃后DBA／2小鼠红细胞数升高较明显；SCID小鼠灌服沙棘油后红细胞及白细胞数均较灌胃前有明显升高，但血小板数无明显变化；用沙棘油灌胃治疗化疗后造血功能障碍动物模型，第8天后血细胞数高于阴性对照组，死亡率减少。结论：沙棘油能促进红细胞系造血，并与G—CSF一样具有促进化疗后骨髓造血功能恢复的作用。 |
| 关 键 词： | 沙棘油 造血功能重建 实验研究 化疗 |
| 修稿时间： | 2002年4月23日 |
The Study on the Effects of the Oil from Hippophae rhamnoides in Hematopoiesis |
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| Chen Yunxian ,Zhong Xueyun ,Liu Tianhao ,Ge Zhihong.The Study on the Effects of the Oil from Hippophae rhamnoides in Hematopoiesis[J].Jorunal of Chinese Medicinal Materials,2003,26(8):572-575. | |
| Authors: | Chen Yunxian Zhong Xueyun Liu Tianhao Ge Zhihong |
| Institution: | Chen Yunxian 1,Zhong Xueyun 2,Liu Tianhao 3,Ge Zhihong 4 |
| Abstract: | Objective: To investigate the possibility of the oil from Hippophae rhamnoides (OHR) in supporting the hematopoitic reconstitution after high dose chemotherapy Method: The mice were fed with OHR and variation of blood cell counts of the mice was recorded Animal models of myelosuppression were built by 5 Fu intra peritoneal infusion The effects of OHR in the hematopoietic reconstitution were observed Results: The counts of erythrocytes of OHR group were significantly elevated The blood cell counts in myelosuppression mice fed with OHR exceeded those in control group, and the mortality was decreased Conclusion: OHR can improve the hematopoiesis of erythroid linage Like G CSF, OHR can stimulate the recovery of hematopoiesis after chemotherapy |
| Keywords: | Hippophae rhamnoides Chemotherapy Hematopoitic reconstitution |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |