| 桦树皮抗肿瘤作用及对免疫功能的影响 |
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| 引用本文： | 韩淑英,李智伟,李岩,宗瑞义.桦树皮抗肿瘤作用及对免疫功能的影响[J].中药材,2000,23(6):343-345. |
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| 作者姓名： | 韩淑英 李智伟 李岩 宗瑞义 |
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| 作者单位： | 1. 华北煤炭医学院,唐山,063000
2. 白求恩医科大学 |
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| 摘 要： | 目的：探讨桦树此抗肿瘤作用及其作用机制。方法：应用桦树皮提取物（ＥＢＢ）口服观察其对小鼠不同肿瘤的抑制作用。免疫功能检测的方法为胸腺（脾）指数的测定及脾细胞对ＣｏｎＡ刺激的反应性和ＮＫ细胞活性的测定。结果：ＥＢＢ抑制小鼠Ｓ１８０瘤、Ｂ１６黑色素瘤和Ｌｅｗｉｓ肺癌的生长；并能延长Ｓ１８０和ＥＡＳ腹水癌小鼠生存期；ＥＢＢ还可使荷瘤小鼠胸腺（脾）指数增大及增强荷瘤鼠脾细胞对ＣｏｎＡ刺激的反应性和ＮＫ细胞
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| 关 键 词： | 桦树皮 肿瘤抑制率 NK细胞 抗肿瘤作用 免疫功能 |
| 修稿时间： | 2000年1月17日 |
Antitumor Effect of the Extract of Birch Bark and Its Influence to the Immune Function |
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| Han Shuying,Li Zhiwei,Li Yan,Zhong Ruiyi.Antitumor Effect of the Extract of Birch Bark and Its Influence to the Immune Function[J].Jorunal of Chinese Medicinal Materials,2000,23(6):343-345. |
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| Authors: | Han Shuying Li Zhiwei Li Yan Zhong Ruiyi |
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| Institution: | Northchina Coal Medical College, Tangshan 063000. |
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| Abstract: | Objective: To study the antitumor effect of extract of birch bark (EBB) and its influnce to the immune function of the tumor-bearing mice. Method: EBB was administered orally and the tumor inhibiting effects were observed in tumor-bearing mice.Experiment of the immune function are to examine thymocytes (spleen) index, reaction of spleen to ConA and activiy of NK cell. Results: EBB showed antitumor effect in vivo to B16,S180 and Lewis lung cancer in mice.EBB can significantly prolong survival period of bearing tumor mice.EBB can enhance thymocytes and spleen index in C57 BL/6 mice.EBB can enhance splenic lymphocytes translate and activit of NK cell (P<0.05). Conclusion: EBB have antitumor effect and enhance immune function in bearing tumor mice. |
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| Keywords: | Extraction of birch bark (EBB) Tumor Tumor inhibting rate NK cell |
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