| 星点设计-效应面法优化葛根素提取工艺 |
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| 引用本文： | 孙向阳,张永玲,张振巍,罗小明.星点设计-效应面法优化葛根素提取工艺[J].中药材,2012(6):980-983. |
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| 作者姓名： | 孙向阳 张永玲 张振巍 罗小明 |
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| 作者单位： | 甘肃省临夏州人民医院;中国人民解放军第155中心医院 |
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| 摘 要： | 目的:采用星点设计-效应面法优化葛根素提取过程中的有关工艺参数。方法:以提取时间、料液比为考察因素,葛根素提取率为指标,分别用多元线性模型和二次多项式模型描述考察指标和两个考察因素之间的数学关系,绘制效应面图,确定较优参数并进行验证实验。结果:确定的最佳提取工艺为:料液比1∶8.88(W/V),提取时间为150 min;二项式拟合的相关系数为0.9977,提取率预测值与理论值偏差0.59%。结论:实验结果与模型预测值相符,该工艺可用于葛根中葛根素的提取。
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| 关 键 词： | 葛根 葛根素 星点设计-效应面法 |
Optimal Extraction of Puerarin from Pueraria lobata Based on Central Composite Design and Response Surface Methodology |
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| SUN Xiang-yang,ZHANG Yong-ling,ZHANG Zhen-wei,LUO Xiao-ming.Optimal Extraction of Puerarin from Pueraria lobata Based on Central Composite Design and Response Surface Methodology[J].Jorunal of Chinese Medicinal Materials,2012(6):980-983. |
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| Authors: | SUN Xiang-yang ZHANG Yong-ling ZHANG Zhen-wei LUO Xiao-ming |
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| Institution: | 1 (1.The People′s Hospital of Linxia,Linxia 731100,China;2.The 155th Central Hospital of PLA,Kaifeng 475003,China) |
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| Abstract: | Objective:To optimize the parameters of extraction technology for Puerarin from Pueraria lobata by Central Composite Design-Response Surface Methodology.Methods: Used the ratio of dosage liquid and extraction time as the examination factor,the content of puerarin for the extraction percentage as the index.The multielement linear model and the polynomial model were used to describe the mathematics relation with response surface.Results:The optimal extraction technology was as follows:ratio of herb-to-solvant was 1∶ 8.88(W/V) and extraction time was 150 min.The coefficient correlation was 0.9977 and closed to the predicted value.Conclusion:The results are accordant with model predictions.The technology can be used as the extraction process of puerarin from Pueraria lobata. |
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| Keywords: | Pueraria lobata(Willd ) Ohwi Puerarin CCD-RSM |
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