|
|||||
|
|
| 降脂减肥茶长期毒性实验研究 | |
| 引用本文： | 吕江陵,邹移海,徐勤,张赛霞,张薇,汤少玲,关慧云,王修银.降脂减肥茶长期毒性实验研究[J].中药材,2002,25(6):423-425. |
| 作者姓名： | 吕江陵 邹移海 徐勤 张赛霞 张薇 汤少玲 关慧云 王修银 |
| 作者单位： | 1. 广州市中医中药研究所,广州510130 2. 广州中医大学 3. 广州市中医医院 |
| 基金项目： | 广东省中医药管理局资助课题(98437) |
| 摘 要： | 目的:观察降脂减肥茶的长期毒性。方法:降脂减肥茶高、中、低剂量组按7g/kg、3.2g/kg、1.5g/kg给SD大鼠灌胃,分别相当于临床用量的100倍、50倍、20倍。给药6周、12周和停药3周后,观察大鼠的行为活动、食欲、二便、体重、血液学和血液生化学指标,以及主要脏器系数和病理组织学检查。结果:3个给药组分别与对照组比较,各项指标差异无显著性意义。结论:本品在临床推荐的用药剂量下有一定的安全性。 |
| 关 键 词： | 降脂减肥茶 长期毒性 毒理学 |
| 修稿时间： | 2002年1月28日 |
Long-term Toxicity Experiment with Tea for Descending Lipid and Declining Fat |
|
| Lu Jiangling,Zou Yihai,Xu Qin,Zhang Saixia,Zhang Wei,Tang Shaoling,Guan Huiyun,Wang Xiuyin.Long-term Toxicity Experiment with Tea for Descending Lipid and Declining Fat[J].Jorunal of Chinese Medicinal Materials,2002,25(6):423-425. | |
| Authors: | Lu Jiangling Zou Yihai Xu Qin Zhang Saixia Zhang Wei Tang Shaoling Guan Huiyun Wang Xiuyin |
| Institution: | Guangzhou Academy of TCM, 510130. |
| Abstract: | Objective: To investigate the chronic toxicity of tea for descending lipid and declining fat (TDLDF). Methods: 4 groups Sprague-Dawley rats had respectively been fed with distilled water and TDLDF in 7 g/kg (high dosage), 3.2 g/kg (middle dosage) and 1.5 g/kg(lower dosage) for 12 weeks, the latter were respectively equal to 100, 50 and 20 times clinical dosage. After ig 6, 12 weeks and 3 weeks after discontinuation, the behavior, appetite, excrement and urine, body weight, hematological and biochemical markers, coefficient of the main organs and pathohistological examinination of the rats were investigated. Result: There were no significant differences of the above markers between each experimental group and the control group. Conclusion: The clinical recommended dosage of TDLDF is safe. |
| Keywords: | Tea for descending lipid and declining fat Long-term Toxicity Toxicology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |