逐瘀通脉胶囊辅助治疗老年脑血栓的临床研究及对血管内皮功能的影响

目的:探讨逐瘀通脉胶囊治疗老年脑血栓的临床疗效及作用机理.方法:64例老年脑血栓患者随机分成治疗组(逐瘀通脉胶囊)及对照组(脑络通),治疗前后分别测定血液流变学和血流动力学参数、血清内皮素(ET)、一氧化氮(NO),对其进行比较,以观察其疗效.结果:治疗组治疗后血液流变学和血流动力学参数均较治疗组明显改善(P＜0.05或P＜0.01),且优于对照组(P＜0.05),且治疗后治疗组的ET低于对照组(P＜0.01),而NO水平则高于对照组(P＜0.01).结论:逐瘀通脉胶囊对老年脑血栓患者有较好的疗效,是一种安全有效的药物.

Clinical Study of Zhuyutongmai Capsule on Treating Senile Cerebral Infarction and Effect on Function of Vascular Endothelium

Objective: To evaluate the clinical study of Zhuyutongmai(ZYTM) Capsule in treating senile cerebral infarction and effect on function of vascular endothelium. Methods: Sixty-four aged patients with cerebral infarction were randomly divided into the treated group treated with ZYTM and the control group treaded with Naoluotong. The clinical effect was observed. The hemorrheologic and hemodynamic parameters, the blood levels of endothelin(ET) and nitric oxide(NO) were determined before and after treatment. Results: After treatment of ZYTM, the hemorrheologic and hemodynamic parameters were all significantly improved(P<0.01 or P<0.05), the therapeutic effect of ZYTM was better than that of Naoluotong(P<0.05), compared with the control group after treatment, the level of ET in the treated group were lower(P<0.01), and level of NO were higher(P<0.01). Conclusion: ZYTM has good effect in treating senile cerebral infarction.