| 葛根素脂质体的研制及其大鼠口服吸收 |
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| 引用本文： | 顾一珠,周文,翟光喜.葛根素脂质体的研制及其大鼠口服吸收[J].中药材,2007,30(8):970-973. |
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| 作者姓名： | 顾一珠 周文 翟光喜 |
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| 作者单位： | 1. 山东大学齐鲁医院药学部,山东济南,250012
2. 山东大学药学院,山东济南,250012 |
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| 摘 要： | 目的：制备葛根素脂质体并研究大鼠对其的口服吸收。方法：利用薄膜分散-超声法制备脂质倚，利用超滤法分离游离药物测定包封率，观测脂质体的微观形态与粒径分布；HPLC法测定葛根素脂质体大鼠口服后血浆中的药物含量。结果：脂质体对葛根素的包封率为53．0％，脂质体粒子在电镜下为圆形或椭圆形，粒径范围50-300nm；葛根素脂质体对其水溶液的相对生物利用度为168％。结论：脂质体对葛根素口服吸收有显著促进作用。
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| 关 键 词： | 葛根素 脂质体 包封率 |
| 文章编号： | 1001-4454（2007）08-0970-04 |
| 修稿时间： | 2006-03-29 |
Preparation of Puerarin Liposome and Its Oral Absorption in Rat |
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| GU Yi-zhu,ZHOU Wen,ZHAI Guang-xi.Preparation of Puerarin Liposome and Its Oral Absorption in Rat[J].Jorunal of Chinese Medicinal Materials,2007,30(8):970-973. |
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| Authors: | GU Yi-zhu ZHOU Wen ZHAI Guang-xi |
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| Institution: | 1. Qilu Hospital; 2. College of Pharmacy, Shandong University, Jinan 250012, China |
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| Abstract: | OBJECTIVE: To prepare puerarin liposome and study its oral absorption in rat. METHODS: Liposome was prepared through the way of film dispersion-ultrasonic. Free puerarin in liposome suspension was separated from liposome through ultrafiltration, and then encapsulation ratio of liposome was determined. Micro-morphology of liposme particles was observed under electronic transmission microscope. Puerarin concentration in blood was determined by HPLC. RESULTS: The encapsulation ratio of puerarin in liposome was 53%, and liposome particles were global or elliptical. The diameter range of liposome particies was from 50 nm to 300 nm. The relative availability of puerarin liposme suspension to puerarin solution was 168%. CONCLUSION: Liposome as a drug carrier can enhance the oral absorption of puerarin in rat. |
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| Keywords: | Puerarin Liposome Encapsulation ratio |
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