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山茱萸炮制前后多糖对小鼠免疫功能的影响
引用本文:杜伟锋,王明艳,蔡宝昌.山茱萸炮制前后多糖对小鼠免疫功能的影响[J].中药材,2008,31(5):715-717.
作者姓名:杜伟锋  王明艳  蔡宝昌
作者单位:南京中医药大学江苏省中药炮制重点实验室,江苏南京,210029
摘    要:目的:研究山茱萸生品和制品多糖对免疫低下小鼠免疫功能的影响,以阐明其炮制增效的机理。方法:腹腔注射环磷酰胺制备免疫低下的小鼠模型,以碳粒廓清法测定非特异性免疫功能,血清溶血素测定法测定体液免疫功能,脾淋巴细胞增殖试验测定细胞免疫功能。结果:山茱萸生品和制品多糖均可提高免疫低下小鼠的碳粒廓清指数K和吞噬指数α,增加血清HC50值,明显改善免疫低下小鼠的脾淋巴细胞增殖反应,且制品多糖的作用显著优于生品多糖。结论:山茱萸生品多糖和制品多糖对免疫低下小鼠的非特异性免疫、体液免疫以及细胞免疫功能均有明显促进作用,且山茱萸经酒蒸制后,其多糖的药效显著增强。

关 键 词:山茱萸  多糖  炮制  免疫功能  山茱萸  炮制前后  多糖  小鼠免疫功能  影响  Induced  Immunosuppression  Mice  Immunologic  Function  officinalis  Cornus  Crude  Polysaccharides  增强  蒸制  体液免疫功能  特异性免疫  作用  脾淋巴细胞增殖反应  改善

Effect of Polysaccharides in Crude and Processed Cornus officinalis on the Immunologic Function of Mice with Immunosuppression Induced
DU Wei-feng,WANG Ming-yan,CAI Bao-chang.Effect of Polysaccharides in Crude and Processed Cornus officinalis on the Immunologic Function of Mice with Immunosuppression Induced[J].Jorunal of Chinese Medicinal Materials,2008,31(5):715-717.
Authors:DU Wei-feng  WANG Ming-yan  CAI Bao-chang
Institution:Jiangsu key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nangjing 210029, China. duweifeng200158@sohu.com
Abstract:OBJECTIVE: To investigate the effect of polysaccharides in crude and processed Cornus officinalis on the immunologic function of mice with immunosuppression induced. METHODS: The immunosuppressed mice were induced by Cyclophosphamide. Non-specific immune function was determined by cleaning carbon particle method. Humoral immunity was determined by serum haemolysin formation method. Cellular immunity was determined by proliferation and transformation of spleen lymphocyte method. RESULTS: The polysaccharides in crude and processed Cornus officinalis both markedly increased the carbon particle clearance index K, phagocytic index alpha, serum HC50 and proliferation and transformation of spleen lymphocyte,and the polysaccharides in processed Cornus officinalis was better than the crude one. CONCLUSION: The polysaccharides in crude and processed Cornus officinalis have an enhanced effect on non-specific immunity, specific humoral immunity and specific cellular immunity in immunodeppressed mice, and after being processed with wine, the action of polysaccharides increased markedly.
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