| 蝮蛇蛇毒中小分子肽的纯化及其抑制血小板聚集的作用 |
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| 引用本文： | 吴少瑜,李志琴,张嘉杰,徐伟,朱正光,余传林,吴曙光.蝮蛇蛇毒中小分子肽的纯化及其抑制血小板聚集的作用[J].中药材,2004,27(11):840-842. |
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| 作者姓名： | 吴少瑜 李志琴 张嘉杰 徐伟 朱正光 余传林 吴曙光 |
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| 作者单位： | 第一军医大学药物研究所,广州,510515 |
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| 摘 要： | 本文首次报道从中国蝮蛇蛇毒中分离出一种分子量为1234.616Da的具有抑制血小板聚集作用的小肽SV-PP-1.SV-PP-1能明显抑制ADP诱导的兔血小板聚集,并有剂量依赖性.这是目前从蛇毒中发现的分子量最小的能抑制血小板聚集的蛇毒小肽.
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| 关 键 词： | 蝮蛇蛇毒 小分子肽 血小板 血小板聚集 |
| 修稿时间： | 2004年8月26日 |
Purification of Small Peptide from Agkistrodon blomhoffii Bioe and Its Inhibition on Platelet Aggregation |
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| Wu Shaoyu,Li Zhiqin,Zhang Jiajie,Xu Wei,Zhu Zhengguang,Yu Chuanlin,Wu Shuguang.Purification of Small Peptide from Agkistrodon blomhoffii Bioe and Its Inhibition on Platelet Aggregation[J].Jorunal of Chinese Medicinal Materials,2004,27(11):840-842. |
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| Authors: | Wu Shaoyu Li Zhiqin Zhang Jiajie Xu Wei Zhu Zhengguang Yu Chuanlin Wu Shuguang |
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| Institution: | Institute of Pharmaceutical Sciences, First Military Medical University, Guangzhou. |
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| Abstract: | This is the first report to purify a new peptide SV-PP-1 from Agkistrodon blomhoffii Bioe. SV-PP-1 has molecular weight of 1234.616Da and can inhibit on platelet aggregation.SV-PP-1 significantly inhibited the ADP-induced platelet aggregation. It has been found up to now that SV-PP-1 is the smllest peptide inhibiting on platelet aggregation from snake venom. |
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| Keywords: | Snake venom Peptide Platelet aggregation |
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