| 红丝线提取物对肾性高血压大鼠血压、一氧化氮和内皮素的影响 |
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| 引用本文： | 庄旭丹,吕俊华,杨文忠,杨美玲.红丝线提取物对肾性高血压大鼠血压、一氧化氮和内皮素的影响[J].中药材,2003,26(4):266-268. |
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| 作者姓名： | 庄旭丹 吕俊华 杨文忠 杨美玲 |
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| 作者单位： | 暨南大学药学院,广州,510632 |
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| 基金项目： | 广东省卫生厅资助项目(A1999287)，广东省科技厅科技三项费用资助项目(1998278) |
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| 摘 要： | 目的：观察红丝线提取物对肾性高血压大鼠血压、尿和血清中一氧化氮、一氧化氮合酶及内皮素浓度的影响。方法：采用两肾-夹高血压大鼠模型，连续灌胃给药4周，并于每周末测定血压；给药第4周末留尿测定尿-氧化氮含量，并处死动物取血测血清一氧化氮、一氧化氮合酶及内皮素的浓度变化。结果：红丝线灌胃1周后能使肾性高血压大鼠血压明显下降，血清中一氧化氮合酶以及尿和血清中一氧化氮浓度明显升高，而血浆中内皮素浓度明显降低。作用持续四周。结论：红丝线能降低肾性高血压大鼠的血压，升高一氧化氮合酶以及尿和血清中一氧化氮浓度，降低血浆中内皮素浓度。
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| 关 键 词： | 红丝线 提取物 肾性高血压 大鼠 血压 一氧化氮 一氧化氮合酶 内皮素 |
| 修稿时间： | 2002年11月29 |
Effects of Peristrophe roxburghiana on Blood Pressure, NO and ET in Renal Hypertensive Rats |
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| Zhuang Xudan,Lu Junhua,Yang Wenzhong,Yang Meiling.Effects of Peristrophe roxburghiana on Blood Pressure, NO and ET in Renal Hypertensive Rats[J].Jorunal of Chinese Medicinal Materials,2003,26(4):266-268. |
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| Authors: | Zhuang Xudan Lu Junhua Yang Wenzhong Yang Meiling |
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| Institution: | Pharmacy College of Jinan University, Guangzhou 510632. |
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| Abstract: | Objective:To observe the effects of Peristrophe roxbrughiana( HSX) on blood pressure,NO,No-synthase and ET in the serum and NO in urine in renal hypertensive rats. Methods:The 2K1C(2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 4 weeks. The blood prssure was measured at the end of the each week. At the end of 4 week, the urine was collected and the concentration of NO in the serum or urine, NO-synthease and ET in the serum were measured. Results: HSX (H or L dosage) by ig. for 1 week can significantly lower the blood pressure, increase the levels of NO and NO-synthase in the serum and NO in the urine, reduce the concentration of ET in the serum. The effects have lasted for 4 weeks. Conclusion:HSX played an important role in the renal hypertensive rats. |
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| Keywords: | Peristrophe roxburghiana Renal hypertension Nitric oxide Endothelin Nitric-synthase |
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