齐墩果酸自微乳大鼠在体胃肠道吸收动力学研究

目的:研究齐墩果酸自微乳在大鼠胃肠道的吸收动力学特征。方法:采用大鼠在体胃肠道吸收实验,高效液相色谱法测定药物浓度,根据药物在胃肠道中的减少量来确定药物的吸收。结果:在大鼠胃部,齐墩果酸微乳2h的吸收百分率为10.15%;在小肠中齐墩果酸微乳与胶束的吸收速率常数分别为0.0901/h和0.0486/h,肠道最佳吸收部位依次为十二指肠、回肠、空肠和结肠。结论:自微乳给药系统对齐墩果酸在大鼠胃肠道的吸收有明显的促进作用,显著提高了齐墩果酸的生物利用度。

The Absorption Kinetics of Oleanolic Acid Self-microemulsion in Rat Stomach and Intestine

Objective:To study the absorption kinetics of oleanolic acid self-microemulsion in rat stomach and intestine.Methods:The absorption kinetics were obtained by using the in situ perfusion method in rat.The absorption of drug was determinated by the decrease in stomach and intestine with the HPLC as the detection method.Results:The absorption percent of oleanolic acid microemulsion for 2 hours was 10.15% in stomach;The absorption rate constants of oleanolic acid microemulsion and micelle were 0.0901/h and 0.0486/h in small intestine,respectively;The best absorption segment in intestine was duodenum,ileum,jejunum and colon by turns.Conclusion:The oleanolic acid self-microemulsifying system significantly enhances the absorption of oleanolic acid in the gastrointestinal tract and improves its bioavailability.