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脑心清片对血脂及血黏状态的临床研究
引用本文:伍新林,王明军,邝昱,张伟君,敖勤兴.脑心清片对血脂及血黏状态的临床研究[J].中药材,2008,31(1):171-174.
作者姓名:伍新林  王明军  邝昱  张伟君  敖勤兴
作者单位:中山大学附属第一医院,广东广州,510080
摘    要:目的探讨脑心清片对血脂及血液黏稠度的影响.方法66例原发性高脂血症随机分成三组,设置第1组脑心清片治疗组25例,第2组脑心清片加半量辛伐他汀治疗组19例,第3组全量辛伐他汀对照组22例;8周后进行三组患者的疗效和空腹血脂、血液黏稠度相关指标及毒副作用的比较.结果三组的总有效率和显效率分别为72.00%、32.00%,94.74%、52.63%,100.00%、54.55%;三组患者治疗后各血脂指标均较治疗前明显改善(P<0.05或P<0.01),治疗后组间比较第2组、第3组的疗效较明显优于第1组(P<0.05),第2组、第3组组间对比差异无显著性(P>0.05);三组患者治疗后血黏五项指标均较治疗前明显降低(P<0.05或P<0.01),治疗后组间比较第2组、第3组的低切全血黏度、高切全血黏度变化明显优于第1组(P<0.05),第2组、第3组组间对比差异无显著性(P>0.05);三组患者治疗后毒副作用比较第1组无明显不良反应,优于第2组和第3组.结论脑心清片能明显改善血脂代谢,降低血液黏稠度,改善血液高凝状态,可以有效治疗高脂血症,且无明显毒副作用.

关 键 词:脑心清片  高脂血症  血液高凝状态  辛伐他汀  脑心清片  血脂代谢  血液高凝状态  临床研究  Tablet  Clinical  Research  Viscosity  Blood  高脂血症  不良反应  变化  全血黏度  五项指标  对比差异  改善  患者治疗  血脂指标  显效率  总有效率  结果
文章编号:1001-4454(2008)01-0171-04
修稿时间:2007年9月5日

A Clinical Research of Naoxinqing Tablet′s Effects on Blood Fat and Viscosity
WU Xin-lin,WANG Ming-jun,KUANG -Yu,ZHANG Wei-jun,AO Qin-xing.A Clinical Research of Naoxinqing Tablet′s Effects on Blood Fat and Viscosity[J].Jorunal of Chinese Medicinal Materials,2008,31(1):171-174.
Authors:WU Xin-lin  WANG Ming-jun  KUANG -Yu  ZHANG Wei-jun  AO Qin-xing
Institution:The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Abstract:OBJECTIVE:To investigate the effects on blood fat and viscosity of Naoxinqing tablet. METHODS: 66 patients of primary hyperlipoidemia were randomly divided into three groups. The first group was treated by Naoxinqing tablet, the second group was treated by Naoxinqing and combined with half dose Simvastatin, the third group was treated by full dose Simvastatin. Then the clinical effect, fasting plasma lipid, the index of blood viscosity and side effect of the three group' patients were compared after 8 weeks. RESULTS: The index of blood fat improved obviously after treatment of the three groups ( P < 0.05, P < 0. 01), group 2 and 3 were significantly superior to group 1 (P < 0.05), and no significance between group 2 and 3 (P > 0.05). CONCLUSIONS: The Naoxinqing tablet can improve the metabolism of blood fat, decrease blood viscosity obviously and treat hyperlipoidemia effectively with little side effect.
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