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黄芩甙元和黄芩甙对皮肤真菌与细菌抑制作用的研究
引用本文:杨得坡,胡海燕,黄世亮.黄芩甙元和黄芩甙对皮肤真菌与细菌抑制作用的研究[J].中药材,2000,23(5):272-274.
作者姓名:杨得坡  胡海燕  黄世亮
作者单位:1. 中山大学生命科学院,广州,510275
2. 法国弗郎什-孔泰大学医药学院,贝藏松,25030
摘    要:本文研究了黄芩甙和黄芩甙元对十七种皮肤致病真菌与十六种皮肤细菌的抑制活性。在琼脂药物培养基上,黄芩甙元表现出了对酵母型真菌高度的选择抑制作用,其最低抑制浓度MIC在70~100μg/ml之间,而对皮肤癣菌和丝状霉菌没有活性;黄芩甙则对所有的供试真菌几乎没有作用。另外,与脚气和腋臭有关的负责菌如何固着微球菌、表皮葡萄球菌和干燥棒杆菌等。在黄芩甙元浓度为250μg/ml的条件下,其生长繁殖也能完全抑制

关 键 词:黄芩  黄芩甙  黄芩甙元  抗真菌  抗细菌
修稿时间:1999年11月8日

Study on the Inhibitory Activity, in vitro, of Baicalein and Baicalin against Skin Fungi and Bacteria
Yang Depo,Hu Haiyan,Huang Shiliang,Jean-Pierre Chaumont, Joёlle Millet.Study on the Inhibitory Activity, in vitro, of Baicalein and Baicalin against Skin Fungi and Bacteria[J].Jorunal of Chinese Medicinal Materials,2000,23(5):272-274.
Authors:Yang Depo  Hu Haiyan  Huang Shiliang  Jean-Pierre Chaumont  Joёlle Millet
Institution:School of Life Sciences, University of Zhougshan, Guangzhou 510275.
Abstract:In this paper, we concentrated in examining, in vitro, the antiseptic activity of the baicalein and baicalin upon the seventeen pathogenic skin fungal and sixteen skin bacterial strains, these two flavonic compounds were known principally as the biosubstances of a traditional Chinese medicinal plant: Scutellaria baicalensis. In agar media, the baicalein possessed potent specific activity against the pathogenic yeasts with MICs of 70-100 micrograms/ml; But in the same condition, no inhibitory effect was observed upon dermatophytes and filamentous imperfect fungi for baicalein, and upon all used strains for baicalin. According to the antibacterial test of baicalein, a high efficacy was achieved against certain causative specie of axillary and foot's odour such as Micrococcus sedentarius, Staphylococcus epidermidis, S. hominis and C. xerosis with a MICs inferior to 250 micrograms/ml. The good inhibitory activity of baicalein could be linked to the group hydroxyl (-OH) in position seven of the molecule.
Keywords:Scutellaria baicalensis  Baicalin  Baicalein  Antifungal  Antibacterial
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