| 中药HD02抗脑缺血/再灌注损伤的作用及机制研究 |
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| 引用本文： | 赵丹洋,赵明奇,吴伟康,曾其毅.中药HD02抗脑缺血/再灌注损伤的作用及机制研究[J].中药材,2005,28(12):1083-1085. |
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| 作者姓名： | 赵丹洋 赵明奇 吴伟康 曾其毅 |
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| 作者单位： | 1. 广州市儿童医院,广州,510120
2. 中山大学中西医结合研究所,广州,510080 |
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| 摘 要： | 目的:观察中药HD02制剂对小鼠反复缺血/再灌注损伤脑组织的保护作用.方法:随机分为假手术对照组、缺血再灌注模型组、HD02低、中、高剂量组,采用小鼠全脑反复缺血/再灌注模型,取脑组织进行脑含水量、SOD活性及MDA、Na /K -ATP酶、Ca2 -ATP含量酶的测定.结果:与假手术组比较,模型组脑含水量显著增加(P＜0.01)、SOD活性明显降低、MDA含量明显升高(P＜0.01)、ATP酶有明显下降(P＜0.01),HD02低、中、高剂量组均可明显减少脑组织含水量(P＜0.01)、提高SOD活性,降低MDA含量(P＜0.01),提高缺血/再灌注脑组织ATP酶活性(P＜0.01).结论:中药HD02可减少小鼠缺血/再灌注脑组织的损伤,其机制可能通过提高SOD活性,减轻自由基对组织的氧化损伤,同时保护细胞ATP酶活性从而使脑水肿程度降低,保护缺血再灌注导致的脑组织损伤.
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| 关 键 词： | 脑缺血/再灌注损伤 脑水肿 氧化应激 |
| 收稿时间： | 2005-04-22 |
| 修稿时间： | 2005年4月22日 |
Study on the Anti-Cerebral Ischemia/Reperfusion Injury Effect and It's Mechanisms of HD02 |
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| Zhao Danyang,Zhao Mingqi,Wu Weikang,Zeng Qiyi.Study on the Anti-Cerebral Ischemia/Reperfusion Injury Effect and It''''s Mechanisms of HD02[J].Jorunal of Chinese Medicinal Materials,2005,28(12):1083-1085. |
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| Authors: | Zhao Danyang Zhao Mingqi Wu Weikang Zeng Qiyi |
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| Institution: | Guangzhou Children's Hospital, Guangzhou. |
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| Abstract: | Objective:To study the effect of HD02 on Anti-Cerebral Ischemia/Reperfusion Injury.Methods:The mice cerebral Ischemia/Reperfusion models were randomly divided into three group:control group,I/R group and treating groups(different dosages of HD02).At the end of the experiment,brain tissues were harvested to measure the brain water content,SOD activity,MDA content and the activity of Na~+/K~+-ATP and Ca~2+-ATP enzyme.Results: HD02 could obviously decrease the brain water content (P<0.01) and the MDA content (P<0.01).while,it could also,increase the activity of SOD (P<0.01) and the activity of ATP enzyme (P<0.05).These data showed that there was sever oxidative damage in brain tissue and HD02 could prevent I/R injury in brain. |
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| Keywords: | HD02 |
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