基于Logistic分析的血管性认知障碍中医证素研究

目的通过Logistic分析,探究血管性认知障碍的证素特征。方法将被调查对象分成血管性轻度认知障碍(VMCI)、血管性痴呆(VD)、认知正常3组,首先确定各组的高频症状,在因子分析的基础上确定病性和病位,通过Logistic分析对3组人群进行两两比较,阐述两类血管性认知人群的常见中医证素。结果共收集有血管性危险因素疾病人群722例,其中VMCI患者253例,VD患者214例,认知正常255例。通过频数和因子结果分析,VMCI和VD主要病性为血瘀、气虚、阴虚和火热,认知正常病性为血瘀、火热、气郁、气虚、血虚和阴虚。3组人群两两之间Logistic分析:认知正常与VCMI比较,以气虚为参照,血瘀OR值小于1,以血瘀为参照,气虚、阴虚、火热OR值均大于1;认知正常与VD比较,以火热为参照,血瘀、气虚、阴虚OR值均小于1;以气虚为参照,火热OR值大于1;VD与VMCI相比,似然比检验P>0.05,差异无统计学意义。结论 VMCI、VD的病性主要为血瘀、气虚、阴虚和火热;与认知正常相比,VMCI病性血瘀较为多见;VD病性以血瘀、气虚、阴虚证素较为多见。

Study on Traditional Chinese Medicine Syndrome Elements of Vascular Cognitive Impairment Based on Logistic Analysis

Objective To explore the syndrome characteristics of vascular cognitive impairment by Logistic analysis.Methods The subjects were divided into three groups: vascular mild cognitive impairment(VMCI),vascular dementia(VD),cognitive normal three groups.Firstly,the high-frequency symptoms of each group were determined,and on the basis of factor analysis,the site and character of the disease were determined,the pairwise comparison of the three groups was carried out through logistic analysis,and the probability of the occurrence of the same syndrome element in the two groups was expounded,so as to find the common TCM syndrome elements of the two kinds of vascular cognitive population.Results A total of 722 patients with vascular risk factors were collected,including 253 patients with VMCI,214 patients with VD,and 255 patients with normal cognitive function.According to the results of factor and frequency analysis,the main pathologies of VMCI and VD are blood stasis,qi deficiency,yin deficiency and fiery.The cognitive normal disease is blood stasis,fiery,qi stagnation,qi deficiency,blood deficiency and yin deficiency.Through the logistic analysis of pairwise comparison of the three groups: the normal cognitive and VCMI,with qi deficiency as the reference,the blood stasis OR value is less than 1,with blood sputum as the reference,qi deficiency,yin deficiency,fiery OR value are greater than 1;cognition Normally compared with VD,with fiery as reference,blood stasis,qi deficiency,yin deficiency OR value are less than 1,with qi deficiency as reference,fiery OR value is greater than 1;VD compared with VMCI likelihood ratio test P>0.05,and there had no statistics significance.Conclusion The pathogenesis of VMCI and VD is mainly blood stasis,qi deficiency,yin deficiency and fiery fever.Compared with cognitive normal,VMCI is more common in blood stasis;VD is more common in blood stasis,qi deficiency and yin deficiency syndrome.