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路氏润燥汤治疗原发性干燥综合征口干疗效对照研究
引用本文:聂彦阁,王福斌,王晶.路氏润燥汤治疗原发性干燥综合征口干疗效对照研究[J].世界中医药,2016(7).
作者姓名:聂彦阁  王福斌  王晶
作者单位:1 辽河油田康复医院康复科,兴城,125100; 2 辽河石油勘探局康复医院,建昌,125100
摘    要:目的:探讨路氏润燥汤治疗原发性干燥综合征口干的临床疗效。方法:以2015年1月至2016年1月在我院接受治疗的84例原发性干燥综合征气阴两虚、瘀血阻络证患者为研究对象,采用计算机法随机分为治疗组(42例)和对照组(42例)。治疗组给予口服路氏润燥汤治疗,对照组给予口服硫酸羟化氯喹治疗,对2组的临床疗效、治疗前后血清学指标及治疗过程中不良反应发生情况等进行比较。结果:治疗后,治疗组于对照组治疗的有效率分别为97.62%和85.71%,差别比较具有统计学意义(P0.05)。治疗后,2组患者唾液流率、口干症状VAS评分和中医症候积分均较同组治疗前明显改善,但治疗组改善的更显著(P0.05)。治疗后,2组患者血清RF、ESR及CRP均较同组治疗前明显降低,但治疗组降低的更明显(P0.05)。结论:路氏润燥汤治疗原发性干燥综合征口干具有很好的临床疗效,能够明显的改善口干症状VAS评分、唾液流率和中医症候积分,并能改善患者血清RF、ESR及CRP水平,值得临床推广应用。

关 键 词:原发性干燥综合征  口干症  路氏润燥汤  疗效
收稿时间:2016/3/7 0:00:00

Clinical Control Study of Lushi Runzao Decoction in Treatment of Xerostomia of Primary Sjogren Syndrome
Nie Yange,Wang Fubin,Wang Jing.Clinical Control Study of Lushi Runzao Decoction in Treatment of Xerostomia of Primary Sjogren Syndrome[J].World Chinese Medicine,2016(7).
Authors:Nie Yange  Wang Fubin  Wang Jing
Institution:1 Liaohe Oilfield Rehabilitation Hospital, Xingcheng 125100,China;2 Treatment Center in Rehabilitation Hospital of Liaohe Petroleum Exploration Bureau, Jianchang 125100,China
Abstract:To evaluate the clinical efficacy of Lushi Runzao Decoction in the treatment of xerostomia in primary Sjogren syndrome. Methods: A total of 84 patients with primary drying syndrome of dual deficiency of qi and yin and blood stasis syndrome from January 2015 to January 2016 in our hospital were selected as research objects. They were randomly divided into the treatment group (42 cases) and control group (42 cases) by computer method. Treatment group were given oral Lushi Runzao Decoction, the control group was given oral sulfate hydroxychloroquine treatment. The clinical efficacy of the two groups, serological indexes and and adverse reaction before and after the treatment were compared. Results: After treatment, the the effective rate of the treatment group and the control group were 97.62% and 85.71% respectively, the difference was statistically significant (P<0.05). After treatment, salivary flow rate, dry mouth symptoms, VAS score and Chinese medicine syndromes of the patients in both group improved significantly, but the treatment group had significantly better results (P<0.05). After treatment, the serum RF, ESR and CRP of patients dropped significantly in both groups after the treatment, but the treatment group decreased more obviously (P<0.05). Conclusion: Lushi Runzao Decoction has good efficacy in the treatment of xerostomia in primary Sjogren syndrome, with good improvement in VAS score, salivary flow rate and Chinese medicine syndromes, as well as serum RF, ESR and CRP levels, which is worthy of clinical application.
Keywords:Primary Sjogren syndrome  Xerostomia  Lushi Runzao Decoction  Curative effect
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