鼻渊通窍颗粒治疗慢性鼻-鼻窦炎的效果及对鼻纤毛传输功能的影响

目的:探究鼻渊通窍颗粒治疗慢性鼻-鼻窦炎(CRS)的效果及对鼻纤毛传输功能的影响。方法:选取2014年3月至2015年3月河南省南阳市第一人民医院耳鼻喉科住院治疗且符合纳入标准的CRS300例纳入研究,随机分为对照组和观察组,每组150例;对照组患者接受规范克拉霉素治疗;观察组予鼻渊通窍颗粒治疗。2周为1个疗程,共治疗1个疗程。结束后比较2组患者鼻塞、流涕、鼻涕后漏和嗅觉障碍等症状改善情况、生命质量评分、鼻纤毛传输功能水平。结果:与治疗前比较,治疗后2组各项症状评分及症状评分总分均降低(P<0.01);与对照组比较,观察组治疗后症状评分总分及鼻塞、流涕、鼻涕后漏、嗅觉等各症状评分均明显降低(P<0.05或P<0.01);治疗后2组患者的SNOT-20量表4个方面评分均较治疗前有显著降低(P<0.01),观察组的SNOT-20量表4个方面评分均低于对照组(P<0.01);与治疗前比较,治疗后2照组患者鼻纤毛传输功能提高(P<0.05或P<0.01);与对照组比较,观察组患者鼻纤毛传输功能显著提高(P<0.01);治疗后对观察组总有效率为75.5%,对照组总有效率为64.7%,观察组总有效率显著高于对照组(P<0.01)。结论:鼻渊通窍颗粒不仅能够改善CRS患者的临床症状,而且可以提高患者嗅觉,提高患者生命质量。

Efficacy of Biyuan Tongqiao Granules in Treating Chronic Sinusitis and Effects on Nasal Ciliary Transmission

To investigate the effects of Biyuan tongqiao granules on chronic sinusitis and its effects on nasal ciliary transmission. Methods:A total of 300 cases were selected, who resided in auricular nasal pharyngeal department and were diagnosed as chronic rhinosinusitis complying with the absorbing standards. And they were divided them into control group and test group, with 150 cases in each group. The control group received regular clarithromycin treatment and the test group got Biyuan tongqiao granules. A total of 2 weeks were a treatment period. All received 1 treatment period. After the treatment, the symptoms including nasal chocking, rhinorrhea, snivel afterward spillage and dysosmia, life quality score, transmission function of nasal cilium were compared. Results:Compared with before treatment, score of each symptom and total symptom score of the 2 groups were decreased after treatment (P<0.01); compared with the control group, the runny nose, stuffy nose, nose, leakage, smell symptoms and symptom score of the test group decreased significantly (P<0.05 or P<0.01). After treatment, the scores of 4 aspects of SNOT-20 scale in the 2 groups were significantly lower than those before treatment (P<0.01), and the test group was lower than that of the control group (P<0.01). Compared with before treatment, nasal mucociliary transport of the 2 groups were increased after the treatment (P<0.05 or P<0.01), and the test group was higher than that of the control group (P<0.01). The efficient proportion was 75.5% in the test group, and the control group was 64.7%. The efficient proportion of the test group was significantly higher than that of the control group (P<0.01). Conclusion:Biyuan tongqiao granules can not only improve the clinical symptoms of patients with chronic sinusitis, but also improve the patient''s sense of smell, improve the quality of life of patients.