基于系统药理学的现代中药研究体系

由于系统生物学的高速发展,以及系统生物学对现代药理学领域的深刻影响,近年来正在形成一个新兴的、跨学科分支,即系统药理学（Systems Pharmacology）。然而系统药理学无论在理论和方法上均不成熟。尤其是,如何将系统药理学的思想和理论用于中药研究尚缺乏探索性工作。本文将综述当前系统药理学的最新进展,同时结合研究者的实践,重点介绍如何将药效学、药动学以及网络、组学以及系统分析综合起来,形成一个统一的完整的、可供开展中药药理学、药效学的预测和验证研究的系统模型。从而为从系统水平研究和分析中药和机体的相互作用,以及新药开发、靶点发现、新的治疗策略等提供新的研究方法。文章最后介绍了研究者最新开发的中药系统药理学数据库和分析平台软件。

Systems Pharmacology-Based Research Framework of Traditional Chinese Medicine

Due to rapidly developing systems biology and its profound impact on pharmacology,an emerging transdisciplinary branch of study is taking shape,that is systems pharmacology （SP） . Theory and methodology of systems pharmacology are not yet mature,let alone adopt the thinking and theories of SP to Chinese Medicine research. Based on new advancements of SP and practical research experience,present research introduced how to integrate pharmacokinetics,pharmacodynamics,networks,biology,and systems analysis to form a system model for forecast and validation of TCM pharmacology and pharmacodynamics,in order to provide new methodology for evaluating drug-human interactions,RD of new drugs,target identification,new therapeutic strategies and so on. In the end the paper introduced the newly developed TCM systems pharmacology database and analysis platform.