中成药治疗非ST段抬高型急性冠脉综合征的网状Meta分析

目的:比较并评价中成药治疗非ST段抬高型急性冠脉综合征的疗效差异和在不同评价指标间的治疗优势.方法:选择中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、Embase等主流医学数据库检索中成药治疗非ST段抬高...

Network Meta-analysis of Chinese Medicine Preparations in the Treatment of Non-ST-elevation Acute Coronary Syndrome

Objective:To compare and evaluate the difference of efficiency of Chinese medicine preparations in the treatment of non-ST-segment elevation acute coronary syndrome and the advantages among different clinical indicators.Methods:Randomized controlled trials of Chinese medicine preparations in the treatment of non-ST-segment elevation acute coronary syndrome were searched based on the CNKI,WanFang,PubMed,et al.Clinical indicators including the efficiency of TCM syndrome score,improvement of ECG,and reduction of Nitroglycerin were analyzed through the software of GeMTC and STATA 14.0.The GRADEpro software and the Cochrane risk of bias assessment tool were used for quality assessment.Results:A total of 27 randomized controlled trials and 22 kinds of Chinese medicine preparations were included in the study.The results of network Meta-analysis showed that Xinmaitong Plaster combined Qishen Yiqi Dripping Pills and western medicine,and Jiedu Tongmai Capsules combined western medicine had a good effect on TCM syndrome score.Xintongshu Capsules combined western medicine had a good effect on ECG amelioration.Jiedu Tongmai Capsules combined western medicine and Yangyin Huoxue Granules combined western medicine had a good effect on the reduction of Nitroglycerin.Conclusion:Xinmaitong Plaster,Qishen Yiqi Dripping Pills,Jiedu Tongmai Capsules,Xintongshu Capsules and Yangyin Huoxue Granules had therapeutic advantages in different outcome indexes of non-ST-segment elevation acute coronary syndrome.However,high-quality clinical studies are still needed to provide evidence support in the future due to the limitation of literature quality.