中药序贯联合化疗治疗非小细胞肺癌的减毒增效临床观察

目的:观察中药序贯联合化疗治疗非小细胞肺癌的减毒增效临床疗效。方法:选取2016年10月至2019年9月上海市嘉定区中医医院肿瘤科病房收治的非小细胞肺癌患者100例作为研究对象,采用随机数字表法随机分为观察组和对照组,每组50例,对照组给予常规化疗、观察组在常规化疗基础上加予中药序贯口服治疗,4周期后观察2组临床疗效及不良反应情况。结果:最终纳入患者91例,治疗后观察组在全身状态(KFS)、临床症状改善情况、临床受益率等方面高于对照组(P0.05);且恶心、呕吐(包括急性、延迟性呕吐)、食欲减退等消化道毒性反应,贫血、白细胞减少等骨髓毒性、癌性疲乏的发生率均均低于对照组(P0.05);血小板减少、肝肾功能损害、味觉减退、神经毒性、过敏反应等其他毒性反应的发生率差异无统计学意义(P0.05)。结论:中药序贯治疗联合化疗治疗NSCLC具有减毒增效作用,具有一定的临床推广意义。

Clinical Observation of Chinese Medicine Combined with Chemotherapy on Reducing Toxicity and Increasing Efficiency of Sequential Therapy in the Treatment Non-smallcell Lung Cancer

To Chinese Medicine combined with chemotherapy on reducing toxicity and increasing efficiency of sequential therapy in the treatment non-smallcell lung cancer.Methods:A total of 100 patients with non-small cell lung cancer diagnosed by imaging and pathology or cytology were randomly divided into an observation group and a control group,with 50 patients in each group.The control group received chemotherapy.The observation group received sequential oral administration of Chinese medicine on the basis of routine chemotherapy.After 4 cycles,the clinical efficacy and toxicity of the 2 groups were observed.Results:A total 91 patients were finally included.After treatment,the observation group was higher than the control group in general condition (KPS),improvement of clinical symptoms and clinical benefit rate (P<0.05),and the incidence of nausea,vomiting (including acute and delayed vomiting),loss of appetite and other gastrointestinal toxicity,anemia,leukopenia,myelotoxicity,and other cancer fatigue were lower than the control group (P<0.05).There was no significant difference in the incidence of thrombocytopenia decrease,liver and kidney function damage,Hypoesthesia,neurotoxicity,allergic reaction and other toxic reactions (P>0.05).Conclusion:The sequential treatment of traditional Chinese medicine combined with standard chemotherapy has the effect of increasing the efficacy and reducing the toxicity of NSCLC.It has certain clinical promotion significance.