人参胡桃汤对肺气虚型慢性阻塞性肺疾病疗效及其对免疫系统的影响

目的:观察人参胡桃汤在治疗肺气虚型慢性阻塞性肺疾病(COPD)的临床疗效及对免疫系统的影响,并进行分析。方法:选取2015年1月至2017年1月湖北省中医院门诊和住院确诊为的肺气虚型的COPD患者130例,通过随机分组将患者分为观察组和对照组,每组65例,对照组使用西医基础治疗,观察组在对照组基础上予以方药人参胡桃汤口服,同时对比分析2组患者的中医证候评分、肺功能、生命质量、淋巴细胞CD3~+、CD4~+、CD8~+、CD19~+及血清免疫球蛋白IgA、IgM、IgG的水平。结果:治疗4周后,2组患者的中医证候总评分较治疗前明显降低(P0.05),且观察组优于对照组(P0.05),2组患者的肺功能较治疗前明显改善(P0.05),生命质量与6 min步行距离较前改善(P0.05),治疗4周后对2组患者的淋巴细胞及免疫球蛋白进行比较,其血清CD3~+、CD4~+、CD4~+/CD8~+、CD19~+、IgA、IgM、IgG水平均明显升高,CD8~+水平明显下降,与治疗前比较,差异均有统计学意义(P0.05),且观察组优于对照组(P0.05)。结论:在使用人参胡桃汤后,肺气虚型COPD患者的临床症状明显改善,生命质量得到明显提高,这可能与其的激发患者免疫机制,提高免疫力有关。

Effect of Renshen Hutao Decoction on Lung Qi Deficiency Type COPD and its Effect on the Immune System

To observe the clinical curative effect of Renshen Hutao Decoction in the treatment of lung qi deficiency COPD and its effects on the immune system, and to conduct analysis. Methods:A total of 130 COPD patients were randomly selected from January 2015 to January 2017 from inpatients and outpatients in our hospital diagnosed as lung qi deficiency. They were randomly divided into observation group and control group. The control group was treated with the basic treatment of Western medicine, and the observation group was given Renshen Hutao Decoction on the basis of the control group. The pulmonary function, quality of life, T lymphocyte CD3+, CD4+, CD8+, CD19+ content and serum immunoglobulin IgA, IgM, IgG of two groups were compared. Results:After 4 weeks of treatment, the total score of TCM syndrome in the two groups was significantly lower than that before the treatment (P<0.05), and the observation group was better than the control group (P<0.05). The pulmonary function of patients in two groups were significantly improved compared with before treatment (P<0.05). The quality of life and 6 min walking distance was better than before treatment (P<0.05). The levels of CD3+, CD4+, CD4+/CD8+, CD19+, IgA, IgM and IgG all increased significantly, and CD8+ level decreased significantly. Compared with those before treatment, the difference was statistically significant (P<0.05), and the observation group was better than the control group (P<0.05). Conclusion:After application of Renshen Hutao Decoction, clinical symptoms of patients with lung qi deficiency of COPD significantly improved the quality of life, which could stimulate the immune mechanism of patients and improve immunity.