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血脂康对急性冠状动脉综合征患者炎症因子和MMP的影响
引用本文:林静,徐尚华,熊尚全.血脂康对急性冠状动脉综合征患者炎症因子和MMP的影响[J].世界中医药,2009,4(2):71-73.
作者姓名:林静  徐尚华  熊尚全
作者单位:1. 福建中医学院,福建省福州市闽侯上街华佗路1号,350108
2. 福建省南平市第一医院心内科一区
3. 福建省人民医院心内科
摘    要:目的:通过观察急性冠状动脉综合征(ACS)患者炎性指标和基质金属蛋白酶(MMP)水平的变化,探讨高敏C反应蛋白(hs-CRP)和MMP与ACS的关系及血脂康对其的影响。方法:选择符合诊断的ACS患者54例,对照组10例。54例ACS患者随机分为2个治疗组:血脂康组和阿托伐他汀组。检测血脂康组和阿托伐他汀组(下称治疗组)与对照组治疗前后血清hs-CRP、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)的改变,并进行临床疗效对比。结果:治疗1周后两治疗组血清TC、TG、LDL—C、MMP-2、MMP-9、hs-CRP水平均较对照组有明显降低(P〈0.05),但两治疗组间无显著性差异(P〉0.05)。结论:1)MMP-2、MMP-9、hs—CRP可作为检测斑块不稳定的指标。2)血脂康具有降低血脂水平、降低ACS炎性指标MMP-2、MMP-9、hs-CRP水平的作用,在短期内血脂康与阿托伐他汀具有相似的抗动脉粥样硬化、稳定斑块的作用。

关 键 词:急性冠状动脉综合征  中医药疗法  血脂康  炎症因子  MMP
收稿时间:2008/4/17 0:00:00

The Effect of Xue zhi kang on Inflammatory Factors and Matrix Metalloproteinase in Patients with Acute Coronary Syndromes
Lin Jing,Xu Shanghu,Xiong Shangquan.The Effect of Xue zhi kang on Inflammatory Factors and Matrix Metalloproteinase in Patients with Acute Coronary Syndromes[J].World Chinese Medicine,2009,4(2):71-73.
Authors:Lin Jing  Xu Shanghu  Xiong Shangquan
Institution:Lin Jing, Xu Shanghua, Xiong Shangquan ( 1. Fujian College ofchinse medicine, add. : No. 1 Huatong Road, Minhou Upper Street, Fuzhou City, Fujian Province, Postal code: 350108; 2. Department of Cardiology, First Hospital, Nanping City, Fujian Province; 3. Department of Cardiology, People's Hospital, Fujian Province )
Abstract:Objectives:To observe the effect of Xue zhi kang on serum levels of high-sensitivity C-reactive protein (hs-CRP), matrix metalloprotease in patients with acute coronary syndromes ( ACS), and discuss how those factors correlate with ACS. Methods: Fifty- four patients with ACS were randomly divided into two groups: Xue zhi kang group and atorvastatin group. At the same time, 10 cases of age matched ACS were selected as a control. The serum level of hs-CRP, cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), MMP-2 and MMP-9 were measured before and after treatment. Results:After one week treatment, there were significant reduction of all above serum levels in Xue zhi kang group and atorvastatin group when each was compared with the control group (P 〈0. 05). However, there was no significant difference between Xue zhi kang groups and atorvastatin groups (P 〉0.05). Conclusion: 1 ) MMP-2 and MMP-9 hs-CRP can be used as diagnostic indicator of unstable plaque; 2) Xue zhi kang can relieve blood fat, lower the levels of such ACS inflammatory factors as hs-CRP, MMP-9 and MMP-2, and produce similar effect of antiartherosclerosis and stabilizing plaque as atorvastatin.
Keywords:Acute Coronary Syndromes/Chinese medical therapy  @ Xue zhi kang
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