痹宁胶囊对急性痛风性关节炎大鼠模型IL-1及MMP-9的研究

目的：观察痹宁胶囊对急性痛风性关节炎大鼠模型滑膜组织的抗炎作用。方法：将Wistar大鼠60只，雌雄各半，造模成功后，随机分为空白组、模型组、西药组、中药高剂量组、中药中剂量组、中药低剂量组，药物干预7d。于造模前、造模后、治疗结束处死前测定大鼠右侧足踝关节容积及血白细胞介素-1（Interleukin-1，IL-1），并在处死后将右侧踝关节滑膜组织做常规HE染色，光镜下观察病理滑膜组织并评分。结果：痹宁胶囊有利于大鼠受损的滑膜组织炎症修复，优于西药组，以中药高剂量组为佳。结论：痹宁胶囊对急性痛风性关节炎大鼠模型滑膜组织有明显的抗炎作用。

Study on Effect of Bining Capsule on Levels of IL-1 and MMP-9 of Rats with Acute Gouty Arthritis

Objective：To observe the anti-inflammatory effect of Bin ing Capsule on syno-vial tissue of rats with acute gouty arthritis. Methods： After a successful modeling of 60 half male and half female Wistar rats, they were randomly divided into blank control group, model group, Western medicine group, Chinese medicine high dose group, Chinese medicine middle dose group, and Chinese medicine low close group. They were all intervened by drugs for 7 days. The right ankle volume of rats and the level of Interleukin-1 （ IL-1 ） before modeling, after modeling and the end of treatment were measured. Besides, the synovial tissue of right ankles were put in routine HE staining after the death of rats, in order to observe and score the pathological synovial tissue through light microscopy. Results： Bining Capsule was beneficial to the repair of inflammation of damaged synovial tissue in rats, better than Western medicine group, and the Chi- nese medicine high dose group showed the best effect. Conclusion： Bining Capsule has significant anti-inflammatory effect in synovial tissue of rats model with acute gouty arthritis.