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| 辛开苦降法对功能性消化不良大鼠胃舒缩活动的影响 | |
| 引用本文： | 王奕,郝建军,魏玮,田俊.辛开苦降法对功能性消化不良大鼠胃舒缩活动的影响[J].中医杂志,2010,51(5). |
| 作者姓名： | 王奕 郝建军 魏玮 田俊 |
| 作者单位： | 1. 中华中医药学会,北京市朝阳区樱花园东街甲 2. 武汉市中西医结合医院 3. 北京市宣武区中医医院 4. 华中科技大学同济医学院 |
| 基金项目： | 国家中医药管理局中医药科技专项基金资助(04-05JP11); 首都医学发展基金资助项目(2005-SF-I-013) |
| 摘 要： | 目的观察辛开苦降法对功能性消化不良(FD)模型大鼠胃舒缩活动的影响。方法将24只大鼠随机分为空白组、模型组和胃康宁组,每组8只,适应性喂养7天后,按照夹尾刺激法制备FD模型,造模7天后,胃康宁组大鼠按0.625g/kg体重灌服胃康宁胶囊,每日2次,其他两组给予同体积生理盐水,连续给药12天,于第13天留取血清和胃组织,测定血浆胃动素(MTL)、一氧化氮(NO)含量及胃体组织MTL、一氧化氮合酶(NOS)、Cajal间质细胞(ICC)和胃肠平滑肌细胞(SMC)的表达。结果模型组血浆MTL水平较空白组明显下降,NO水平明显升高,胃肌间神经丛MTL、ICC及SMC的阳性神经元的表达明显减弱,NOS阳性神经元表达明显增加(P0.01);与模型组比较,胃康宁组血浆MTL水平明显升高,NO水平明显降低,胃组织MTL、ICC及SMC的表达明显增强,NOS的表达减少(P0.01)。结论辛开苦降法对FD大鼠的治疗作用与其调节胃舒缩活动有关。 |
| 关 键 词： | 辛开苦降法 功能性消化不良 胃肠运动 胃动素 一氧化氮 |
Effect of TCM Treatment with the Xinkai Kujiang Method on Gastric Motion in Functional Dyspepsia Rats |
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| WANG Yi,HAO Jianjun,WEI Wei,TIAN Jun.Effect of TCM Treatment with the Xinkai Kujiang Method on Gastric Motion in Functional Dyspepsia Rats[J].Journal of Traditional Chinese Medicine,2010,51(5). | |
| Authors: | WANG Yi HAO Jianjun WEI Wei TIAN Jun |
| Institution: | WANG Yi1,HAO Jianjun2,WEI Wei3,TIAN Jun4(1.China Asscociation of Chinese Medicine,Beijing 100029,2.Wuhan Hospital of Integrated Chinese , Western Medicine,3.Beijing Xuanwu Traditional Chinese Medicine Hospital,4.Tongji Medical College,Huazhong University of Science , Technology) |
| Abstract: | Objective To study the effect and mechanism of Xinkai Kujiang method(TCM treatment with the pungent and bitter herbs to regulate the gastrofunctions)on the functional dyspepsia(FD)rats.Methods Twenty-four rats were randomized into control group,model group,and Weikangning(herbal medicine for dyspepsia)group,with 8 in each.After a 7-day adaptive feed,the FD models were made with the clipping tail stimulation.Seven days after modeling,the Weikangning group was given Weikangning Capsule 0.625g/kg by gavage,twi... |
| Keywords: | Xinkai Kujiang method(TCM treatment with the pungent and bitter herbs to regulate the gastrofunctions) Functional dyspepsia Gastrointestinal movement Motilin(MTL) Nitric oxide(NO) |
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