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健儿乐颗粒治疗咳嗽变异型哮喘缓解期儿童52例临床观察
引用本文:刘竹云,王醊恩,于忠翠.健儿乐颗粒治疗咳嗽变异型哮喘缓解期儿童52例临床观察[J].中医杂志,2010,51(4).
作者姓名:刘竹云  王醊恩  于忠翠
作者单位:1. 山东省烟台市中医医院小儿科,烟台市幸福路39号,264002
2. 滨州医学院中西医结合学院
基金项目:山东省中医药科技发展项目(2007-192)
摘    要:目的观察健儿乐颗粒对咳嗽变异型哮喘(CVA)缓解期的临床疗效及安全性。方法将103例CVA缓解期患儿分为两组。治疗组52例给予健儿乐颗粒,对照组51例给予定量吸入二丙酸倍氯米松气雾剂,1个疗程(6个月)结束时统计咳嗽发作情况,分别于治疗前后检测患儿呼气风流速值(PEF)及第一秒用力呼气容积(FEV1)的变化、中医证候评分、血清免疫球蛋白、T细胞亚群,对咳嗽疗效、肺功能疗效和中医证候疗效进行评价。结果两组患儿咳嗽疗效及肺功能疗效比较差异无统计学意义(P0.05),治疗组的中医证候疗效明显优于对照组(P0.01),两组治疗后比较血清IgA、IgG、CD8变化有统计学意义(P0.05);治疗组患儿治疗前后实验室检查无异常改变,未发现不良反应。结论健儿乐颗粒可防治CVA发作、改善临床症状和免疫功能,阻止其向典型哮喘发展。

关 键 词:健儿乐颗粒  咳嗽变异型哮喘  缓解期  中医证候疗效  

Observation on the Effect of Jianerle Granule for the Remission Stage of Children Cough Variant Asthma:A Report of 52 Cases
LIU Zhuyun,WANG Zhuien,YU Zhongcui.Observation on the Effect of Jianerle Granule for the Remission Stage of Children Cough Variant Asthma:A Report of 52 Cases[J].Journal of Traditional Chinese Medicine,2010,51(4).
Authors:LIU Zhuyun  WANG Zhuien  YU Zhongcui
Institution:LIU Zhuyun1,WANG Zhuien2,YU Zhongcui1 (1. Yantai TCM Hospital of Sh,ong Province,Yantai 264002,2. Integrated Medic ine College,Binzhou Medical University)
Abstract:Objective To observe the effect and safety of Jianerl e Granule (Granule for children) on cough variant asthma (CVA) of remission sta ge. Methods Totally 103 CVA cases of remission stage were divided into a treatment gro up (52 cases) treated by Jianerle Granule for six months and a control group ( 51 cases) treated by Beclomethasone Dipropionate Inhaler. After one course (6 mo nthes) of treatment, the condition of cough attacks was analyzed. The changes in pressu re of expiratory flow (PEF) and forced expi...
Keywords:Jianerle Granule (Granule for children)  Cough vari ant asthma (CVA)  Remission stage  Effect on TCM symptoms  
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