补肾强督方对50例强直性脊柱炎继发骨质疏松症患者血清骨保护素、骨密度及骨代谢的影响

目的 研究补肾强督方对强直性脊柱炎(AS)继发骨质疏松症患者的疗效及机理.方法 应用补肾强督方治疗50例AS骨质疏松症患者6个月,检测患者治疗前后血清骨保护素(OPG)、骨密度,血清骨钙素(BGP)、降钙素(H-CT)、甲状旁腺激素(PTH)、骨特异性碱性磷酸酶(BAP)、Ⅰ型胶原羧基端延长肽(CICP)、尿脱氧吡啶啉(DPD)、Ⅰ型胶原交联C末端肽(CTX)、血沉(ESR)、C-反应蛋白(CRP),观察治疗前后患者功能指数(BASFI)、病情活动指数(BASDI)及症状、体征的变化.结果治疗后患者血清OPG水平、骨密度、BGP、BAP显著升高(P＜0.05或P＜0.01),DPD、CTX显著下降(P＜0.01);ESR、CRP、BASFI、BASDAI、症状、体征等明显改善.结论 补肾强督方可以提高AS患者的血清OPG、骨密度水平,调节AS患者的骨代谢及免疫水平.

Effect of Bushen Qiangdu Formula on Serum Osteoprotegerin,Bone Mineral Density and Bone Metabolism of 50 Patients of Osteoporosis with Ankylosing Spondylitis

Objective To study the effect of and its mechanism Bushen Qiangdu Formula(Formula for reinforcing kidney and strengthening spine)on patients with osteoporosis induced by ankylosing spondylitis(AS).Methods All 50 AS patients with osteoporosis were treated with Bushen Qiangdu Formula for six months.Before and after treatment,the observation term includes serum osteoprotegerin(OPG),bone mineral density(BMD),serum boneglaprotein(BGP),calcitonin(H-CT),parathyroid hormone (PTH),bone-specific alkaline phosphatase(BAP),collagen Ⅰ carboxyl-terminal-prolonging peptides(CICP),urine deoxidation pydidinoline(DPD),C-telopeptide of type Ⅰ collagen(CTX-Ⅰ),erythrocyte sedimentation rate(ESR),C reactive protein(CRP),Bath AS Function Index(BASFI),Bath AS dynamic Index(BASDI),and symptoms and signs.Results After treatment,the serum OPG significantly increased(P＜0.05),BMD greatly raised(P＜0.05 or P＜0.01),BGP and BAP obviously up-regulated(P＜0.05or P＜0.01),and their DPD and CTX significantly decreased(P＜0.01);and got their ESR,CRP,BASFI,BASDI,and symptoms and signs tremendously improved.Conclusion Bushen Qiangdu Formula is effective to increase the serum OPG and BMD,and regulate the bone metabolism and immunity of AS patients.