| 肝气郁证模型大鼠下丘脑单胺类神经递质分析 |
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| 引用本文： | 张惠云,乔明琦,孙丽.肝气郁证模型大鼠下丘脑单胺类神经递质分析[J].中医杂志,2008,49(2):150-152. |
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| 作者姓名： | 张惠云 乔明琦 孙丽 |
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| 作者单位： | 山东中医药大学科技处,济南市长清大学科技园大学路4655号,250355 |
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| 基金项目： | 国家重点基础研究发展规划(973计划) |
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| 摘 要： | 目的探讨肝气郁证模型大鼠发病的微观机制。方法捆绑法造模制作肝气郁证模型大鼠,采用反相离子高效液相色谱(RP-IP-HPLC)测定大鼠造模后下丘脑中去甲肾上腺素(NE)、肾上腺素(E)、多巴胺(DA)及5-羟色胺(5-HT)4种神经递质含量变化。结果肝气郁证模型大鼠下丘脑中E、DA、5-HT水平显著升高(P<0.05或P<0.01),NE水平显著降低(P<0.01),且用药后均得到明显改善。结论肝气郁证与下丘脑中NE、E、DA、5-HT关系密切。
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| 关 键 词： | 肝气郁证 下丘脑 单胺类神经递质 高效液相色谱 肝气郁证 模型 大鼠下丘脑 单胺类 神经递质分析 Syndrome Stagnation Models Hypothalamus Neurotransmitters Monoamine 关系 改善 用药 平显 结果 含量变化 羟色胺 多巴胺 去甲肾上腺素 |
| 修稿时间： | 2006年10月16 |
Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome |
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| ZHANG Hui-yun,QIAO Ming-qi,SUN Li.Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome[J].Journal of Traditional Chinese Medicine,2008,49(2):150-152. |
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| Authors: | ZHANG Hui-yun QIAO Ming-qi SUN Li |
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| Abstract: | Objective To study the mechanism of liver-qi stagnation syndrome of rat models. Methods The binding method was used to make rat models of liver-qi stagnation syndrome and the quantitative changes of hypothalamus norepinephrine (NE), epinephrine (E), dopamine (DA), and 5-hydroxytryptamine (5-HT) before and after modeling were determined with reversed phase ion pair (RP-IP)-HPLC. Results The level of E, DA and 5-HT was remarkably increased (P<0.05 or P<0.01) while NE decreased significantly (P<0.01), and they were all improved after medication. Conclusion The liver-qi stagnation syndrome is closely related with level of hypothalamus NE, E, DA and 5-HT. |
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| Keywords: | Liver-qi stagnation syndrome Hypothalamus Monoamine neurotransmitters High performance liquid chromatography (HPLC) |
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