| 复方白及糊对反流性食管炎模型大鼠食管黏膜的影响 |
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| 引用本文： | 唐艳萍,弓艳霞,李淑红,王瑞,刘思邈,李方儒,魏玮.复方白及糊对反流性食管炎模型大鼠食管黏膜的影响[J].中医杂志,2011,52(15):1312-1315,1321. |
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| 作者姓名： | 唐艳萍 弓艳霞 李淑红 王瑞 刘思邈 李方儒 魏玮 |
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| 作者单位： | 1. 天津市南开医院消化内科,天津市南开区三纬路122号,300100
2. 中国中医科学院望京医院消化内科 |
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| 摘 要： | 目的探讨复方白及糊防治反流性食管炎的作用机制。方法将Wistar大鼠随机分为假手术组、全程中药组、造模后中药组及生理盐水组,每组23只。除假手术组外,其余3组均制备反流性食管炎大鼠模型。全程中药组造模前7天起,每天灌胃复方白及糊3ml,共21天;造模后中药组造模后开始每天灌胃等量中药,共14天;生理盐水组同时灌胃等量生理盐水。分别于术后7天、14天观察各组大鼠食管下段pH、大体标本及组织学改变,同时检测食管黏膜胃泌素(GAS)、胃动素(MOT)、血管活性肠肽(VIP)、一氧化氮(NO)水平。结果 2个中药组可使模型大鼠食管下段pH升高,损伤黏膜迅速修复,使食管黏膜GAS、MOT表达增强,VIP、NO表达减少,其中全程中药组与生理盐水组、假手术组比较差异有统计学意义(P<0.05)。结论复方白及糊可能通过局部黏膜保护、调节多种胃肠道激素及神经递质,增加下食管括约肌压力,促进胃排空,对反流性食管炎起防治作用的。
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| 关 键 词： | 复方白及糊 反流性食管炎 胃泌素 胃动素 血管活性肠肽 一氧化氮 |
Influence of Compound Hyacinth Bletilla Paste on the Esophageal Mucosa of Acidic Reflux Esophagitis Model Rats |
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| TANG Yanping,GONG Yanxia,LI Shuhong,WANG Rui,LIU Simiao,LI Fangru,WEI Wei.Influence of Compound Hyacinth Bletilla Paste on the Esophageal Mucosa of Acidic Reflux Esophagitis Model Rats[J].Journal of Traditional Chinese Medicine,2011,52(15):1312-1315,1321. |
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| Authors: | TANG Yanping GONG Yanxia LI Shuhong WANG Rui LIU Simiao LI Fangru WEI Wei |
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| Institution: | TANG Yanping1,GONG Yanxia1,LI Shuhong1,WANG Rui 1,LIU Simiao1,LI Fangru1,WEI Wei 2(1.Tianjin Nankai Hospital,Tianjin 300100,2.Wangjing Hospitall,China Academy of Chinese Medical Sciences) |
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| Abstract: | Objective To explore the functional mechanism of Compound Hyacinth Bletilla Paste in the treatment and prevention of acidic reflux esophagitis.Methods The Wistar rats were randomized into 4 groups,including the sham-operation group,the whole process Chinese medicine group,post-modeling Chinese medicine group,and normal saline group,23 in each.Except the sham-operation group,the other three groups were all made acidic reflux esophagitis models.The whole process Chinese medicine group was administered Compoun... |
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| Keywords: | Compound Hyacinth Bletilla Paste reflux esophagitis gastrin(GAS) motilin(MOT) vasoactive intestinal peptides(VIP) nitric oxide(NO) |
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