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| 中药分期序贯治疗轻中度溃疡性结肠炎111例疗效观察 | |
| 引用本文： | 沈洪,张声生,王垂杰,赵文霞,叶柏,周滔,李玉锋,韩捷,郑凯,顾培青,崔超,邹建东,朱磊.中药分期序贯治疗轻中度溃疡性结肠炎111例疗效观察[J].中医杂志,2011,52(13):1108-1111. |
| 作者姓名： | 沈洪 张声生 王垂杰 赵文霞 叶柏 周滔 李玉锋 韩捷 郑凯 顾培青 崔超 邹建东 朱磊 |
| 作者单位： | 1. 南京中医药大学附属医院,南京市汉中路155号,210029 2. 首都医科大学附属北京中医医院 3. 辽宁中医药大学附属医院 4. 河南中医学院第一附属医院 |
| 基金项目： | "十一五"国家科技支撑计划，国家自然科学基金 |
| 摘 要： | 目的评价中药分期序贯治疗方案对轻中度溃疡性结肠炎(UC)的临床疗效。方法按照多中心、随机、对照、非劣效性研究设计,将4个临床中心的239例轻中度UC患者随机分为试验组及对照组,试验组分阶段予以清肠化湿方汤剂口服、灌肠方灌肠及清肠方汤剂口服,对照组口服美沙拉嗪肠溶片,疗程24周。记录治疗前及治疗后2、4、8、12、16、20和24周的症状积分,比较两组患者症状积分变化,评价临床疗效。结果 239例患者中,符合方案有效病例204例,试验组111例,对照组93例。治疗结束时,试验组症状总有效率87.4%,对照组症状总有效率84.9%,试验组的症状总有效率非劣效于对照组(P<0.05)。治疗前后症状积分比较,试验组在治疗第8周时对症状总积分的改善优于对照组(P<0.01),在第4周和第8周对腹胀和腹痛的改善分别优于对照组(P<0.05)。结论中药分期序贯治疗方案对轻中度UC患者的症状有明显改善作用,并能较快地诱导患者症状的缓解,尤其对腹胀、腹痛的改善早于西药治疗。 |
| 关 键 词： | 溃疡性结肠炎 序贯疗法 中药灌肠 |
Effect of Stage Sequential Treatment of Chinese Medicine on 111 Cases of Mild to Moderate Ulcerative Colitis |
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| SHEN Hong,ZHANG Shengsheng,WANG Chuijie,ZHAO Wenxia,YE Bai,ZHOU Tao,LI Yufeng,HAN Jie,ZHENG Kai,GU Peiqing,CUI Chao,ZOU Jiandong,ZHU Lei.Effect of Stage Sequential Treatment of Chinese Medicine on 111 Cases of Mild to Moderate Ulcerative Colitis[J].Journal of Traditional Chinese Medicine,2011,52(13):1108-1111. | |
| Authors: | SHEN Hong ZHANG Shengsheng WANG Chuijie ZHAO Wenxia YE Bai ZHOU Tao LI Yufeng HAN Jie ZHENG Kai GU Peiqing CUI Chao ZOU Jiandong ZHU Lei |
| Institution: | SHEN Hong1,ZHANG Shengsheng2,WANG Chuijie3,ZHAO Wenxia4,YE Bai 1,ZHOU Tao2,LI Yufeng3,HAN Jie4,ZHENG Kai 1,GU Peiqing1,CUI Chao2,ZOU Jiandong1,ZHU Lei 1(1.The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing210029,2.Beijing TCM Hospital Affiliated to Capital Medical University,3.The Affiliated Hospital of Liaoning University of Chinese Medicine,4.The First Affiliated Hospital of Henan University of Chinese Medicine) |
| Abstract: | Objective To evaluate the effect of stage sequential treatment of Chinese medicine on mild to moderate ulcerative colitis(UC).Methods A multi-central,randomized-controlled,and non-inferiority designed study was carried out.Totally 239 patients from four clinical centers with mild to moderate UC were randomized into study group and control group.The study group received the stage sequential treatment of Chinese medicine,i.e.,the decoction of Qingchang Huashi Recipe(Recipe for clearing intestine and dissolvin... |
| Keywords: | ulcerative colitis(UC) stage sequential treatment enema with Chinese medicine decoction |
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