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降脂通络软胶囊治疗非酒精性脂肪性肝病患者60例临床观察
引用本文:张仁义,李松芝.降脂通络软胶囊治疗非酒精性脂肪性肝病患者60例临床观察[J].中医杂志,2012,53(18):1577-1579,1591.
作者姓名:张仁义  李松芝
作者单位:1. 齐河县中医院,山东省齐河县齐晏大街554号,251100
2. 黑龙江省鹤岗市人民医院
摘    要:目的 观察降脂通络软胶囊治疗菲酒精性脂肪性肝病(NAFLD)的临床疗效. 方法 将120例NAFLD患者随机分为治疗组和对照组各60例.对照组在一般治疗基础上给予辛伐他汀片,每次10mg,每晚1次;硫普罗宁肠溶片,每次200mg,每日3次.治疗组在一般治疗基础上给予降脂通络软胶囊,每次2粒,每日3次.两组均连续治疗12周.观察两组患者治疗前后临床症状体征、体重指数(BMI)、腰围、血压、血脂、肝功能及CT影像学指标.结果 治疗组总有效率91.67,%,对照组85.00%,两组比较差异无统计学意义(P>0.05),治疗组显效率51.67%优于对照组33.33%(P<0.05);两组治疗后BMI、腰围、血压均较治疗前有改善(P<0.05),但治疗组BMI、腰围改善更明显(P<0.05);两组治疗后肝功能、血脂、肝/脾CT值均较治疗前明显改善(P<0.05或P<0.01),并且治疗组肝功能、血脂、肝/脾CT值改善更明显(P<0.05或P<0.01).结论 降脂通络软胶囊具有调脂保肝、改善代谢指标的疗效,可以多靶点起效治疗NAFLD.

关 键 词:降脂通络软胶囊  非酒精性脂肪性肝病  调脂  保肝

Clinical Observation on Jiangzhi Tongluo Gelatin Capsule for 60 Patients with Nonalcoholic Fatty Liver Disease
ZHANG Renyi,LI Songzhi.Clinical Observation on Jiangzhi Tongluo Gelatin Capsule for 60 Patients with Nonalcoholic Fatty Liver Disease[J].Journal of Traditional Chinese Medicine,2012,53(18):1577-1579,1591.
Authors:ZHANG Renyi  LI Songzhi
Institution:1.TCM Hospital of Qihe County,Shandong Province 251100;2.The People’ s Hospi tal of Hegang,Heilongjiang Province)
Abstract:Objective To observe the therapeutic effect of Jiang z hi Tongluo Gelatin Capsule(capsule to lower the lipid and free the network vessels) for nonalcoho lic fatty liver disease(NAFLD).Methods Totally 120 ca ses of NAFLD were randomi zed into treatment group and control group,with 60 in each.The control gro up was given simvastatin tablets,10mg per time,once every evening,and tiopron in enteric-coated tablets,200mg per time,three times daily on the basis of co nventional treatment.The treatment group was given Jiangzhi Tongluo Gelatin Cap s ule,2 capsules per time,three times daily on the basis of conventional treatme nt.Both groups were treated for 12 weeks.The symptoms,signs,body mass index(BMI),waist circumference(WC),blood pres sure(BP),blood lipid,liver function and computed tomography(CT) imaging were observed before and after treatment.Results The total effective rate of the tr eatment group and control group was 91.67% and 85.00% respectively,with no sig nificant difference between groups(P>0.05).The excellent rate of the treatmen t gro up and control group was 51.67% and 33.33% respectively,with significant diff erence between groups(P<0.05).BMI,WC and BP improved significantly in bo th gr oups after treatment(P<0.05),especially BMI and WC in the treatment group(P<0.05).Alanine transaminase(ALT),gamma-glutamyl acyl transfer peptidase(GGT),aspartate aminotransferase(AST),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and liver/spleen CT ratio decreased significantly in both groups after tr eatment(P<0.01),especially TC,TG,HDL-C,LDL-C and liver/spleen CT ra tio in t he treatment group(P<0.05 or P<0.01).Conclusion Jiangzhi Tongluo Gelatin Capsu le is a multi-target onset drug for NAFLD and it could effectively regulate blo od lipid,protect the liver and improve the metabolic.
Keywords:Jiangzhi Tongluo Gelatin Capsule(capsule to lower th e lipid and free the network vessels)  nonalcoholic fatty liver disease  blood l ipid regulation  liver protection
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