柴胡疏肝散对功能性消化不良肝气郁结证患者胃动力及胃肠激素的影响

目的探讨功能性消化不良肝气郁结证患者可能的发病机制及柴胡疏肝散的干预作用。方法选择35例功能性消化不良肝气郁结证患者(治疗组)及20名健康志愿者(健康对照组),治疗组给予柴胡疏肝散治疗4周,观察治疗后中医症状总疗效,单项症状疗效及胃肠激素、胃排空、胃电图、饮水试验情况,并结合心理评估报告,同时与健康对照组比较。结果治疗组治疗前后总体评分比较均有统计学差异(P0.05)。若以单项有效率统计,上腹饱胀不适、早饱、上腹痛、上腹烧灼感、恶心、呕吐、嗳气、纳差、急躁易怒抑郁、口苦、头晕乏力、反酸及大便溏软13项症状均有改善(P0.05)。餐后不适综合征和上腹痛综合征两亚型间比较无统计学差异(P0.05)。治疗后胃排空延迟较治疗前好转(P0.05);胃电图餐前、餐后正常慢波有所提高;饮水量明显增加(P0.05);胃动素水平较治疗前升高,促肾上腺皮质激素释放激素(CRH)水平较治疗前下降,餐后瘦素水平较治疗前上升(P0.05);患者抑郁症状有所减轻,停药3个月后症状基本无反复。结论柴胡疏肝散能够很好地改善FD肝气郁结证患者临床证候,促进胃排空,改善胃电图,降低内脏敏感性,改善胃肠激素水平,改善抑郁症状。

Effect of Chaihu Shugan Powder on Gastric Motility and Gastrointestinal Hormone of Functional Dyspepsia Patients with Liver-qi Stagnation

Objective To study the pathogenesis of functional dyspepsia with liver-qi stagnation and the effect of Chaihu Shugan Powder (Bupleurum powder for relieving liver-qi stagnation).Methods Thirty-five cases of functional dyspepsia with liver-qi stagnation were taken as treatment group and 20 healthy volunteers were put into control group. The treatment group was administered Chaihu Shugan Powder for four weeks to observe the total effective rate of symptoms and effective rate of single symptoms, and the changes...