化痰药半夏、瓜蒌、浙贝母、石菖蒲对大鼠血液流变性的影响

目的：探讨“痰瘀同源”理论及研究化痰药对血液流变性的影响。方法：观察半夏、瓜蒌、浙贝母、石菖蒲对正常大鼠全血粘度、红细胞变形指数、血浆纤维蛋白原含量的影响。结果：化痰药有降低全血粘度、明显抑制红细胞的聚集（除瓜蒌外）和提高红细胞的变形能力等作用。在高切变率时,石菖蒲和浙贝轻度增加全血粘度。石菖蒲有轻度增高血浆纤维蛋白原含量的趋势。结论：提示化痰亦能祛瘀,化痰药降低血粘度的机理与降血脂及抗脂质过氧化有关。

Effects of Some Drugs for Resolving Phlegm on Blood Rheological Property in Rats

In order to study on the theory of " phlegm and blood stasis having same source" and effects of drugs for resolving phlegm on blood rheology, effects of Ban Xia, Gua Lou, Zhe Bei Mu and Shi Chang Pu on whole blood viscosity, erythrocyte deformation index and plasma fibrinogen content in normal rats. Results indicated that the drugs.for resolving phlegm had functions of decreasing whole blood viscosity, inhibiting hemoagglutination (except Gua Lou) and increasing capability of erythrocyte deformation; at high shearing rate, Shi Chang Pu and Zhe Bei Mu could slightly increase whole blood viscosity: Shi Chang Pu increased slightly plasma fibrinogen content. It is suggested that resolving phlegm also can removing blood stasis, and the mechanism of the drug for resolving phlegm in decreasing blood viscosity is related with decrease of blood lipids and anti - peroxidation of lipids.