中药内服加灌肠治疗慢性溃疡性结肠炎31例临床观察

目的 观察中药内服配合灌肠治疗慢性溃疡性结肠炎(UC)大肠湿热证的临床疗效.方法 64例UC患者随机分为治疗组31例,给予中药汤剂内服并配合灌肠治疗；对照组33例,给予口服美沙拉嗪每次1g,每日4次.连续治疗8周后评价临床疗效、中医证候疗效、主要症状评分及肠黏膜评分,观察不良反应. 结果 治疗组临床疗效、证候疗效总有效率均为87.1％,对照组均为75.8％,两组比较差异均有统计学意义(P＜0.05).两组患者治疗后腹痛、腹泻、脓血便症状积分均明显降低(P＜0.05),并且治疗组治疗后腹痛、腹泻积分明显低于对照组(P＜0.05)；治疗后治疗组肠黏膜积分改善优于对照组(P＜0.05).结论 中药内服配合灌肠治疗UC大肠湿热证疗效肯定,能明显改善临床症状,且无明显不良反应.

Clinical Observation on Chronic Ulcerative Colitis treated by Chinese Herbal Decoction for Oral Taking and Enema : a Report on 31 Cases

Objective To observe the effect of Chinese herbal decoction for oral taking and enema on chronic ulcerative colitis (UC) with the large intestine damp heat syndrome in TCM. Methods Sixty-four UC patients were randomized into treatment group of 31 cases treated by Chinese herbal decoction for oral taking and enema, and control group of 33 cases medicated by mesalamine 1g each time, 4 times a day. After the treatment for 8 weeks in succession, the clinical effect and TCM syndrome effect were evaluated with the main symptom scores and intestinal mucosa scores. And the adverse reactions were also observed. Results The total effective rate of the treatment group was 87.1%, better than 75.8% of the control group (P<0.05). The symptom scores including abdominal pain, diarrhea, and purulent bloody stool of the patients of both groups were significantly lowered (P<0.05), and the scores of abdominal pain and diarrhea of the treatment group were significantly lower than those of the control group (P<0.05). The improvement of the intestinal mucosa score of the treatment group was better than that of the control group (P<0.05). Conclusion Chinese herbal decoction for oral taking and enema is effective for chronic UC with the large intestine damp heat syndrome in TCM.