中药引经理论与靶向给药

目的:通过探讨中药引经理论与现代靶向给药思想之间的关系,为中医引经理论的现代应用提供展望和设想,以期更好的发扬中医理论精华.方法:调研中医引经理论、中药归经思想以及中药药代动力学及生理、生物药剂等研究结果,归纳比较,提出论点及验证方法.结果:中药引经理论与现代靶向给药思想具有相通之处,目前生理学及分子生物学等技术的研究成果可为揭示其内在联系提供方法.结论:引经理论有可能应用于靶向给药系统的设计,克服目前靶向制剂存在的缺点.引经理论与靶向给药关系的研究有助于中医理论的发扬光大,同时可推动引经药作用机理以及物质作用基础等的研究.

TCM Medicinal Guide Theory and Target-tropism Administration

Objective:To provide prospect and ideas for modern apply of TCM medicinal guide theory so as to better develop essence of TCM theories by means of studies on relation between TCM medicinal guide theory and modern target-tropism administration thought. Methods:Investigate,research,summarize and compare TCM medicinal guide theory,TCM channel tropism thought,and achievements of studies on TCM pharmacokinetics,physiology and biological preparation,and put forward argument and methods to test and verify.Results:TCM medicinal guide theory and modern target-tropism administration thought have similar points. Present achievements of studies on physiological and molecular biological techniques can provide methods for revealing their internal relations.Conclusion:The medicinal guide theory may apply to design the target-tropism administration system and overcome shortcomings of present target preparations.Studies on relation of the medicinal guide theory with target-tropism administration can help develop TCM theories and promote the studies on mechanisms of the channel-tropism drugs.