| 脂脉康颗粒对痰浊阻遏证高脂血症患者脂质过氧化的影响 |
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| 引用本文： | 李典鸿,靳利利,卞继芳,梁宏宇,黄培红,苏慧.脂脉康颗粒对痰浊阻遏证高脂血症患者脂质过氧化的影响[J].中医杂志,2010,51(1). |
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| 作者姓名： | 李典鸿 靳利利 卞继芳 梁宏宇 黄培红 苏慧 |
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| 作者单位： | 广东省第二中医院一内科,广州市恒福路60号,510095 |
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| 基金项目： | 广东省中医药管理局资助项目(A103087) |
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| 摘 要： | 目的观察脂脉康颗粒对高脂血症(痰浊阻遏证)患者的抗动脉粥样硬化作用。方法将120例高脂血症患者随机分为治疗组和对照组,每组60例。治疗组给予脂脉康颗粒,每次1袋,每日2次,饭前服用。对照组给予舒降之20mg,每晚临睡前口服。两组均以45天为1个疗程。观察患者超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)含量治疗前后变化。结果治疗组及对照组治疗后NO及血清SOD活性均较治疗前明显升高(P0.01或P0.05),两组治疗后血清MDA的浓度均明显降低(P0.01)。治疗组治疗后SOD、NO升高优于对照组,两组治疗后MDA水平差异无统计学意义(P0.05)。结论脂脉康颗粒剂能提高抗氧化酶的活性,抗自由基反应,抑制脂质过氧化损伤,保护内皮细胞,而具有抗动脉粥样硬化作用。
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| 关 键 词： | 脂脉康颗粒剂 高脂血症 痰浊阻遏证 动脉粥样硬化 脂质过氧化 |
Effect of Zhimaikang Granules on Lipid Peroxidation of Hyperlipidemia Patients with Syndrome of Phlegm Turbidity Retention |
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| LI Dianhong,JIN Lili,BIAN Jifang,LIANG Hongyu,HUANG Peihong,SU Hui.Effect of Zhimaikang Granules on Lipid Peroxidation of Hyperlipidemia Patients with Syndrome of Phlegm Turbidity Retention[J].Journal of Traditional Chinese Medicine,2010,51(1). |
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| Authors: | LI Dianhong JIN Lili BIAN Jifang LIANG Hongyu HUANG Peihong SU Hui |
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| Institution: | LI Dianhong,JIN Lili,BIAN Jifang,LIANG Hongyu,HUANG Peihong,SU Hui(The Second TCM Hospital of Guangdong Province,Guangzhou 510095) |
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| Abstract: | Objective To study the effect of Zhimaikang Granules (Granules for lipid abnormality) on atherosclerosis of hyperlipidemia patients of phlegm turbidity retention type.Methods Totally 120 hyperlipidemia patients were randomized into treatment group and control group, 60 cases in each. The treatment group was administered Zhimaikang Granules, each time 1 bag, twice a day. The control group was given Simvastatin Tablets, oral taking before sleeping. Both groups were treated for 45 days. Changes of superoxide d... |
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| Keywords: | Zhimaikang Granules (Granules for lipid abnormality) Hyperlipidemia Syndrome of phlegm turbidity retention Atherosclerosis Lipid peroxidation |
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