Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens |
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Authors: | Merup Mats Lazarevic Vladimir Nahi Hareth Andreasson Björn Malm Claes Nilsson Lars Brune Mats LeBlanc Katarina Kutti Jack Birgegård Gunnar;Swedish Group for Myeloproliferative Disorders |
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Institution: | Department of Haematology, Karolinska University Hospital, Stockholm, Sweden. mats.merup@ki.se |
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Abstract: | Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations. |
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Keywords: | myelofibrosis allogeneic transplantation reduced intensity conditioning Cervantes score |
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