Designer probiotics: Development and applications in gastrointestinal health |
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Authors: | Roy D Sleator |
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Institution: | Roy D Sleator, Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland |
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Abstract: | Given the increasing commercial and clinical relevance of probiotics, improving their stress tolerance profile and ability to overcome the physiochemical defences of the host is an important biological goal. Herein, I review the current state of the art in the design of engineered probiotic cultures, with a specific focus on their utility as therapeutics for the developing world; from the treatment of chronic and acute enteric infections, andtheir associated diarrhoeal complexes, to targeting HIV and application as novel mucosal vaccine delivery vehicles. |
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Keywords: | Gastrointestinal tract Probiotics BetL Listeria monocytogenes Bifidobacterium Lactobacillus |
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