Role of CaMKII in the regulation of fatty acids and lipid metabolism |
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| Authors: | Jitcy S Joseph Krishnan Anand Sibusiso T Malindisa Oladapo F Fagbohun |
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| Institution: | 1. Department of Toxicology and Biochemistry, National Institute for Occupational Health, A Division of National Health Laboratory Service, Johannesburg, South Africa;2. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa;3. Department of Life and Consumer Sciences, University of South Africa (UNISA), Florida Park, Johannesburg, South Africa;4. Department of Biomedical Engineering, First Technical University, Ibadan, Oyo State, Nigeria;5. Department of Pediatrics, Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada |
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| Abstract: | Background & aimsPrevious studies have reported the beneficial roles of the activation of calmodulin-dependent protein kinase (CaMK)II to many cellular functions associated with human health. This review aims at discussing its activation by exercise as well as its roles in the regulation of unsaturated, saturated, omega 3 fatty acids, and lipid metabolism.MethodsA wide literature search was conducted using online database such as ‘PubMed’, ‘Google Scholar’, ‘Researcher’, ‘Scopus’ and the website of World Health Organization (WHO) as well as Control Disease and Prevention (CDC). The criteria for the search were mainly lipid and fatty acid metabolism, diabetes, and metabolic syndrome (MetS). A total of ninety-seven articles were included in the review.ResultsCalmodulin-dependent protein kinase activation by exercise is helpful in controlling membrane lipids related with type 2 diabetes and obesity. CaMKII regulates many health beneficial cellular functions in individuals who exercise compared with those who do not exercise. Regulation of lipid metabolism and fatty acids are crucial in the improvement of metabolic syndrome.ConclusionsApproaches that involve CaMKII could be a new avenue for designing novel and effective therapeutic modalities in the treatment or better management of metabolic diseases such as type 2 diabetes and obesity. |
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| Keywords: | CaMKII Type 2 diabetes Obesity Metabolic syndrome Lipid oxidation |
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