| 慢加急性肝衰竭患者血清中乳酸脱氢酶的临床意义 |
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| 引用本文： | 陈丽,罗二平,朱海超,黄小平,甘建和.慢加急性肝衰竭患者血清中乳酸脱氢酶的临床意义[J].胃肠病学和肝病学杂志,2010,19(4). |
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| 作者姓名： | 陈丽 罗二平 朱海超 黄小平 甘建和 |
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| 作者单位： | 苏州大学附属第一医院感染科,江苏,苏州,215006 |
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| 基金项目： | 国家"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项"十一五"(2008专项) |
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| 摘 要： | 目的研究慢加急性肝衰竭(ACLF)患者血清中乳酸脱氢酶(LDH)的变化特点及其临床意义。方法比较我院37例ACLF患者病程早、中、晚期血清中LDH的变化;并比较存活组与死亡组血清LDH水平的差异;分析患者血清LDH与总胆红素、凝血酶原时间、全身炎症反应综合征(SIRS)发生率、终末期肝病(MELD)评分及病死率的相关性。结果血清LDH值在ACLF早、中、晚期逐渐升高(F=10.93,P0.001);ALT/LDH值逐渐降低(F=21.09,P0.001);死亡组LDH(365.0 u/L±237.6 u/L)显著高于存活组(209.6 u/L±71.7 u/L)(t=4.88,P0.001);LDH升高程度与凝血酶原时间、MELD评分、SIRS发生率、病死率具有相关性(r值分别为0.63、0.856、0.97、0.96;P值分别为0.001、0.001、0.02、0.035)。结论LDH在ACLF早、中、晚期逐渐升高;LDH升高提示ACLF预后不良。
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| 关 键 词： | 肝衰竭 乳酸脱氢酶 预后 |
Clinical significance of serum Lactate dehydrogenase in patients with acute-on-chronic liver failure |
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| CHEN Li,LUO Erping,ZHU Haichao,HUANG Xiaoping,GAN Jianhe.Clinical significance of serum Lactate dehydrogenase in patients with acute-on-chronic liver failure[J].Chinese Journal of Gastroenterology and Hepatology,2010,19(4). |
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| Authors: | CHEN Li LUO Erping ZHU Haichao HUANG Xiaoping GAN Jianhe |
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| Institution: | CHEN Li,LUO Erping,ZHU Haichao,HUANG Xiaoping,GAN Jianhe Department of Infectious Disease,the First Affiliated Hospital of Soochow University,Suzhou 215006,China |
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| Abstract: | Objective To study the change of serum lactate dehydrogenase(LDH) in patients with acute-on-chronic liver failure(ACLF),and to investigate its clinical significance.Methods Serum LDH in 37 ACLF patients was compared mutually during nonage,metaphase,and anaphase.LDH was also compared between the survival group and the expired group.Correlation of LDH with pro-time,model for end-stage liver disease(MELD) scores,SIRS incidence rate,or mortality was analyzed.Results Serum LDH was higher in anaphase patients tha... |
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| Keywords: | Liver failure Lactate dehydrogenase Prognosis |
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