中国幽门螺杆菌耐药研究现状

中国是一个幽门螺杆菌（H．pylori）感染率较高的国家，H．pylori的感染率42％～90％，所以H．pylori感染的治疗是H．pylori研究领域中的重点，而H．pylori感染治疗失败主要原因是H．pylori对抗生素的耐药性，所以H．pylori感染治疗中核心问题是日．pylori对抗生素的耐药性，其耐药性也是H．pylori感染研究中的重点课题。近年我国对H．pylori耐药研究已有新j生展，本文重点介绍如下5个方面：①H．pylori对常用抗生素耐药情况及地区差异性；②H．pylori对常用抗生素耐药性随时间变迁而逐渐上升；⑧H．pylori对四环素和左氧氟沙星耐药情况；④H．pylori耐药对H．pylori根除效果的影响；⑤如何克服H．pylori对抗生素耐药性。

Antibiotic resistance status of H.pylori in China

Helicobacter pylori （H. pylori） infection rate is very high in China. The prevalence rate is 40% - 84%. So the study of the treatment is very important in the research area of H. pylori infection, while the key point is the antibiotic resistance. The antibiotic resistance is the main cause to lead to the failure of H. pylori eradication treatment. The review article summarizes the update for antibiotic resistance status of H. pylori in China. The characteristics of H. pylori resistance include five aspects： （1） The prevalence and the regional disparity of H. pylori resistance to antibiotics; （2） H. pylori resistance to common used antibiotics is on the increase by the time ; （3） The status of H. pylori resistance to tetracycline and levofloxacin ; （4） The influence of H. pylori resistance to antibiotics on the treatment outcome of H. pylori infection; （5） How to prevent the antibiotic-resistance of H. pylori.