| 慢传输性便秘结肠阿片受体的病理生理改变 |
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| 引用本文： | 王亚旭,时德,刘宝华. 慢传输性便秘结肠阿片受体的病理生理改变[J]. 现代消化及介入诊疗, 2001, 6(4): 36-38 |
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| 作者姓名： | 王亚旭 时德 刘宝华 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所普通外科 |
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| 摘 要： | 目的 为了更加深入地了解慢传输性便秘的发病机理和病理生理改变。方法 应用放射配体结合分析检测了患结肠mu、Kappa阿片受体含量变化。结果 与正常对照组比较，STC患结肠壁肌层ma、Kappa阿片受体含量增加。结论 STC患内源性阿片肽活性增加，肠道运动受抑制，提示阿片受体拮抗剂可能是治疗STC的一个新途径。
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| 关 键 词： | 结肠 病理生理改变 慢传输性便秘 患者 阿片受体拮抗剂 治疗 肠道运动 Kappa阿片受体 对照组 正常 |
Pathophysiologic changs of colonic opioid receptors in slow transit constipation |
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| Wang Ya-xu. Pathophysiologic changs of colonic opioid receptors in slow transit constipation[J]. Modern Digestion & Intervention, 2001, 6(4): 36-38 |
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| Authors: | Wang Ya-xu |
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| Abstract: | Object To study furtherly about STC in its mechanism and pathophysiology. Method The content of mu and kappa opiod receptors in colon were studied in radioligand binding assay(RBA) in STC.Result The content of mu and kappa opioid receptors in STC colon are increased compared to control group. Conclusion It expressed that activity of endogenous opioid peptides was increased and the intestinal motility was inhibited in STC. |
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| Keywords: | Slow transit constipation Pathophysiology Instestinal motility Opioid receptor |
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