| 雷公藤多苷对溃疡性结肠炎小鼠结肠组织IL-1、TNF-α、IL-13的影响 |
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| 引用本文： | 钟继红,刘英超,王章流,等.雷公藤多苷对溃疡性结肠炎小鼠结肠组织IL-1、TNF-α、IL-13的影响[J].中国中西医结合消化杂志,2014(5):242-244. |
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| 作者姓名： | 钟继红 刘英超 王章流 等 |
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| 作者单位： | 浙江中医药大学附属第二医院消化科,浙江杭州310005 |
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| 基金项目： | 浙江省教育厅科研资助项目（No：Y201329099） |
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| 摘 要： | 目的]观察雷公藤多苷对溃疡性结肠炎模型小鼠IL-1、TNF-α、IL-13的影响.方法]采用右旋葡聚糖硫酸钠法（DSS）复制BALB/c小鼠溃疡性结肠炎模型,雷公藤多苷灌胃给药7d后,采用ELISA酶联法检测结肠组织匀浆蛋白细胞因子（IL-1、TNF-α和IL-13）的含量.结果]雷公藤多苷组小鼠结肠组织中IL-1、TNF-α含量明显下降（P＜0.05）,IL-13含量上升.结论]雷公藤多苷通过影响细胞因子水平而达到抗溃疡性结肠炎的作用.
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| 关 键 词： | 雷公藤多苷 溃疡性结肠炎 细胞因子 |
Effect of tripterygium glycosides on colon tissue of ulcerative colitis in mice IL-1,TNF-α, IL-13 |
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| ZHONG Ji-hong,LIU Ying-chao,WANG Zhang-liu,JIANG Xiang-hong,SHEN Yan.Effect of tripterygium glycosides on colon tissue of ulcerative colitis in mice IL-1,TNF-α, IL-13[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2014(5):242-244. |
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| Authors: | ZHONG Ji-hong LIU Ying-chao WANG Zhang-liu JIANG Xiang-hong SHEN Yan |
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| Institution: | (Department of Gastroenterology,2nd Hospital affiliated to Zhejiang University of Chinese Medicine, Hangzhou 310005 ,China) |
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| Abstract: | Objective]To observe the effects of Tripterygium glycosides on ulcerative colitis in mice model IL-1,TNF-α,IL-13.Methods]Using dextran sodium sulfate（DSS）method to copy the model of BALB/c mice ulcerative colitis,Tripterygium glycosides was administered for 7 days,and using ELISA method detection of cytokines in colon tissue homogenate protein（IL-1,TNF-α and IL-13）levels.Results] IL-1 and TNF-αlevel decrease significantlyin Tripterygium glycosides group mice colon tissue（P＜0.05）,but the level of IL-13increases（P＞0.05）.Conclusion]Through affecting the levels of cytokines,Tripterygium glycosides can reach to anti-ulcer colitis. |
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| Keywords: | tripterygium glycosides ulcerative colitis cytokine |
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